(7R,8R)-(+)-7-hydroxy-9-p-toluenesulfonyloxy-2-methyloctadecane

Base Information

Chemical Name:(7R,8R)-(+)-7-hydroxy-9-p-toluenesulfonyloxy-2-methyloctadecane
CAS No.:105243-11-6
Molecular Formula:C₂₆H₄₆O₄S
Molecular Weight:454.715
Hs Code.:

Synonyms:

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Chemical Property of (7R,8R)-(+)-7-hydroxy-9-p-toluenesulfonyloxy-2-methyloctadecane

Chemical Property:

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Technology Process of (7R,8R)-(+)-7-hydroxy-9-p-toluenesulfonyloxy-2-methyloctadecane

There total 13 articles about (7R,8R)-(+)-7-hydroxy-9-p-toluenesulfonyloxy-2-methyloctadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 105243-10-5
(7R,8R)-(+)-7-acetoxy-8-p-toluenesulfonyloxy-2-methyloctadecane

: 105243-11-6
(7R,8R)-(+)-7-hydroxy-9-p-toluenesulfonyloxy-2-methyloctadecane

Guidance literature:: With acetyl chloride; In methanol; Ambient temperature;

Reference yield:

: 70240-41-4
4-methyl-1-pentyltriphenylphopshonium bromide

: 105243-11-6
(7R,8R)-(+)-7-hydroxy-9-p-toluenesulfonyloxy-2-methyloctadecane

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) NaH, DMSO / 1.) 1 h, 2.) 60 deg C, 2 h

2: 83 percent / H₂ / 5percent Pd/C / ethanol / 72 h / 760 Torr / Ambient temperature

3: 86 percent / NaH, DMSO / 2 h

4: 62 percent / 85percent aq. CF₃COOH / 1,2-dimethoxy-ethane / 48 h / Ambient temperature

5: lead tetraacetate / benzene

6: 1.) BuLi / 1.) THF, hexane, 5 deg C, 1 h, 2.) THF, hexane, -60 deg C, 1 h

7: water / methanol / Ambient temperature

8: 93 percent / pyridine

9: 88 percent / H₂ / 5percent Pd/C / acetic acid / 2 h / 20 °C / 760 Torr

10: 93 percent / pyridine / 96 h / -10 - 20 °C

11: 58 percent / acetyl chloride / methanol / Ambient temperature

With pyridine; lead(IV) acetate; n-butyllithium; water; hydrogen; sodium hydride; dimethyl sulfoxide; acetyl chloride; trifluoroacetic acid; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; ethanol; acetic acid; benzene;

Reference yield:

: 60902-45-6
nonyltriphenylphosphonium bromide

: 105243-11-6
(7R,8R)-(+)-7-hydroxy-9-p-toluenesulfonyloxy-2-methyloctadecane

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) BuLi / 1.) THF, hexane, 5 deg C, 1 h, 2.) THF, hexane, -60 deg C, 1 h

2: water / methanol / Ambient temperature

3: 93 percent / pyridine

4: 88 percent / H₂ / 5percent Pd/C / acetic acid / 2 h / 20 °C / 760 Torr

5: 93 percent / pyridine / 96 h / -10 - 20 °C

6: 58 percent / acetyl chloride / methanol / Ambient temperature

With pyridine; n-butyllithium; water; hydrogen; acetyl chloride; palladium on activated charcoal; In methanol; acetic acid;