1-FLUORO-1-DEOXY-D-FRUCTOSE

Base Information

• Chemical Name: 1-FLUORO-1-DEOXY-D-FRUCTOSE
• CAS No.: 40614-94-6
• Molecular Formula: C₆H₁₁FO₅
• Molecular Weight: 182.149
• Mol file: 40614-94-6.mol

Synonyms:

Chemical Property of 1-FLUORO-1-DEOXY-D-FRUCTOSE

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-FLUORO-1-DEOXY-D-FRUCTOSE

There total 4 articles about 1-FLUORO-1-DEOXY-D-FRUCTOSE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-fluoro-O2,O3;O4,O5-diisopropylidene-β-D-1-deoxy-fructopyranose (40614-93-5) → 1-deoxy-1-fluoro-D-fructose (40614-94-6)

Guidance literature:

With Bio-Rad AG 50W-X₈; In ethanol; water; at 60 - 70 ℃; for 3h;

DOI:10.1021/ja00330a051

Reference yield:

2,3;4,5-di-O-isopropylidene-β-D-fructopyranose (20880-92-6) → 1-deoxy-1-fluoro-D-fructose (40614-94-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / pyridine / CH₂Cl₂ / 1.5 h / -15 °C

2: 80 percent / tetrahydrofuran / Heating

3: 81 percent / Bio-Rad AG 50W-X₈ / ethanol; H₂O / 3 h / 60 - 70 °C

With pyridine; Bio-Rad AG 50W-X₈; In tetrahydrofuran; ethanol; dichloromethane; water;

DOI:10.1021/ja00330a051

Reference yield:

2,3:4,5-di-O-isopropylidene-1-O-(trifluoromethanesulfonyl)-β-D-fructopyranose (74925-15-8) → 1-deoxy-1-fluoro-D-fructose (40614-94-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / tetrahydrofuran / Heating

2: 81 percent / Bio-Rad AG 50W-X₈ / ethanol; H₂O / 3 h / 60 - 70 °C

With Bio-Rad AG 50W-X₈; In tetrahydrofuran; ethanol; water;

DOI:10.1021/ja00330a051

upstream raw materials:

1-fluoro-O²,O³;O⁴,O⁵-diisopropylidene-β-D-1-deoxy-fructopyranose

2,3;4,5-di-O-isopropylidene-β-D-fructopyranose

2,3:4,5-di-O-isopropylidene-1-O-(trifluoromethanesulfonyl)-β-D-fructopyranose

Refernces