2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)-N'-hydroxyacetimidamide

Base Information

Chemical Name:2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)-N'-hydroxyacetimidamide
CAS No.:1584731-77-0
Molecular Formula:C₂₈H₃₇Cl₂N₃O₄S
Molecular Weight:582.591
Hs Code.:

2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)-N'-hydroxyacetimidamide

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Chemical Property of 2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)-N'-hydroxyacetimidamide

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Technology Process of 2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)-N'-hydroxyacetimidamide

There total 3 articles about 2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)-N'-hydroxyacetimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₃₄Cl₃NO₄S

: 1584731-77-0
2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)-N'-hydroxyacetimidamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / water / 3 h / 0 °C / Inert atmosphere

2: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

3: sodium hydrogencarbonate; hydroxylamine hydrochloride / methanol / Inert atmosphere; Reflux

With hydroxylamine hydrochloride; ammonia; sodium hydrogencarbonate; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm401911v

Reference yield:

: 1352066-48-8
2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

: 1584731-77-0
2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)-N'-hydroxyacetimidamide

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: ammonia / water / 3 h / 0 °C / Inert atmosphere

3: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

4: sodium hydrogencarbonate; hydroxylamine hydrochloride / methanol / Inert atmosphere; Reflux

With 4-methyl-morpholine; hydroxylamine hydrochloride; ammonia; sodium hydrogencarbonate; triethylamine; trifluoroacetic anhydride; isobutyl chloroformate; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm401911v

Reference yield:

: 1584731-40-7
2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetamide

: 1584731-77-0
2-((3R,5R,6S)-1-((S)-1-(tert-butylsulfonyl)butan-2-yl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)-N'-hydroxyacetimidamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

2: sodium hydrogencarbonate; hydroxylamine hydrochloride / methanol / Inert atmosphere; Reflux

With hydroxylamine hydrochloride; sodium hydrogencarbonate; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; methanol;
DOI:10.1021/jm401911v