(S)-5-(2,6-Dimethoxy-phenyl)-1,2,3,4-tetrahydro-naphthalen-2-ylamine

Base Information

Chemical Name:(S)-5-(2,6-Dimethoxy-phenyl)-1,2,3,4-tetrahydro-naphthalen-2-ylamine
CAS No.:756818-61-8
Molecular Formula:C₁₈H₂₁NO₂
Molecular Weight:283.37
Hs Code.:
ChEMBL ID:CHEMBL184666
DSSTox Substance ID:DTXSID701169624

Synonyms:CHEMBL184666;DTXSID701169624;BDBM50150675;(S)-5-(2,6-Dimethoxy-phenyl)-1,2,3,4-tetrahydro-naphthalen-2-ylamine;756818-61-8;(2S)-5-(2,6-Dimethoxyphenyl)-1,2,3,4-tetrahydro-2-naphthalenamine

Suppliers and Price of (S)-5-(2,6-Dimethoxy-phenyl)-1,2,3,4-tetrahydro-naphthalen-2-ylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-5-(2,6-Dimethoxy-phenyl)-1,2,3,4-tetrahydro-naphthalen-2-ylamine

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:283.157228913
Heavy Atom Count:21
Complexity:323

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C(=CC=C1)OC)C2=CC=CC3=C2CCC(C3)N
Isomeric SMILES:COC1=C(C(=CC=C1)OC)C2=CC=CC3=C2CC[C@@H](C3)N

Technology Process of (S)-5-(2,6-Dimethoxy-phenyl)-1,2,3,4-tetrahydro-naphthalen-2-ylamine

There total 5 articles about (S)-5-(2,6-Dimethoxy-phenyl)-1,2,3,4-tetrahydro-naphthalen-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 735279-27-3
(S)-2-trifluoroacetamido-5-(2,6-dimethoxyphenyl)tetralin

: 756818-61-8
(S)-5-(2,6-Dimethoxy-phenyl)-1,2,3,4-tetrahydro-naphthalen-2-ylamine

Guidance literature:: With hydrogenchloride; acetic acid; at 125 ℃; for 2h;
DOI:10.1021/jm0498102

Reference yield:

: 105086-92-8,105086-80-4
(S)-5-methoxy-2-amino-1,2,3,4-tetrahydronaphthalene

: 756818-61-8
(S)-5-(2,6-Dimethoxy-phenyl)-1,2,3,4-tetrahydro-naphthalen-2-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂

2: BBr₃ / CH₂Cl₂

3: Et₃N / CH₂Cl₂

4: Na₂CO₃; LiCl; Pd(PPh₃)4 / toluene; ethanol / 6 h / 95 °C

5: AcOH; aq. HCl / 2 h / 125 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; sodium carbonate; acetic acid; triethylamine; lithium chloride; In ethanol; dichloromethane; toluene; 4: Suzuki cross-coupling;
DOI:10.1021/jm0498102

Reference yield:

: 735279-24-0
(S)-2-trifluoroacetylamino-5-methoxy-1,2,3,4-tetrahydronaphthalene

: 756818-61-8
(S)-5-(2,6-Dimethoxy-phenyl)-1,2,3,4-tetrahydro-naphthalen-2-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: BBr₃ / CH₂Cl₂

2: Et₃N / CH₂Cl₂

3: Na₂CO₃; LiCl; Pd(PPh₃)4 / toluene; ethanol / 6 h / 95 °C

4: AcOH; aq. HCl / 2 h / 125 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; sodium carbonate; acetic acid; triethylamine; lithium chloride; In ethanol; dichloromethane; toluene; 3: Suzuki cross-coupling;
DOI:10.1021/jm0498102