trimethyl (2R,3S,4R,5S)-5-(3-methoxyphenyl)pyrrolidine-2,3,4-tricarboxylate

Base Information

• Chemical Name: trimethyl (2R,3S,4R,5S)-5-(3-methoxyphenyl)pyrrolidine-2,3,4-tricarboxylate
• CAS No.: 1420291-82-2
• Molecular Formula: C₁₇H₂₁NO₇
• Molecular Weight: 351.356
• Mol file: 1420291-82-2.mol

Synonyms:

Chemical Property of trimethyl (2R,3S,4R,5S)-5-(3-methoxyphenyl)pyrrolidine-2,3,4-tricarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trimethyl (2R,3S,4R,5S)-5-(3-methoxyphenyl)pyrrolidine-2,3,4-tricarboxylate

There total 2 articles about trimethyl (2R,3S,4R,5S)-5-(3-methoxyphenyl)pyrrolidine-2,3,4-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl [(3-methoxybenzylidene)amino]acetate (868659-08-9) + dimethyl cis-but-2-ene-1,4-dioate (624-48-6) → trimethyl (2R,3S,4R,5S)-5-(3-methoxyphenyl)pyrrolidine-2,3,4-tricarboxylate (1420291-82-2) + trimethyl 5-(3-methoxyphenyl)pyrrolidine-2,3,4-tricarboxylate + trimethyl 5-(3-methoxyphenyl)pyrrolidine-2,3,4-tricarboxylate

Guidance literature:

With C₄₆H₄₂N₂O₂P₂; silver trifluoromethanesulfonate; potassium carbonate; In dichloromethane; at 20 ℃; for 48h; Overall yield = 89 %; Overall yield = 78.2 mg; stereoselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1055/s-0032-1316779

Reference yield:

methyl [(3-methoxybenzylidene)amino]acetate (868659-08-9) + dimethyl cis-but-2-ene-1,4-dioate (624-48-6) → trimethyl (2R,3S,4R,5S)-5-(3-methoxyphenyl)pyrrolidine-2,3,4-tricarboxylate (1420291-82-2) + trimethyl (2R,3R,4S,5S)-5-(3-methoxyphenyl)pyrrolidine-2,3,4-tricarboxylate

Guidance literature:

methyl [(3-methoxybenzylidene)amino]acetate; With C₄₆H₄₂N₂O₂P₂; silver trifluoromethanesulfonate; In dichloromethane; for 1h; Inert atmosphere; Molecular sieve;

dimethyl cis-but-2-ene-1,4-dioate; With potassium carbonate; In dichloromethane; Overall yield = 89 %; Overall yield = 78.2 mg; stereoselective reaction; Inert atmosphere;

DOI:10.1055/s-0032-1316779

upstream raw materials:

methyl [(3-methoxybenzylidene)amino]acetate

dimethyl cis-but-2-ene-1,4-dioate