C₂₂H₂₁FN₆

Base Information

• Chemical Name: C₂₂H₂₁FN₆
• CAS No.: 1422438-36-5
• Molecular Formula: C₂₂H₂₁FN₆
• Molecular Weight: 388.447
• Mol file: 1422438-36-5.mol

Synonyms:

Chemical Property of C₂₂H₂₁FN₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₁FN₆

There total 9 articles about C₂₂H₂₁FN₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C27H29FN6O2 → C22H21FN6 (1422438-36-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃;

DOI:10.1016/j.bmcl.2015.09.052

Reference yield:

C11H10FN3 → C22H21FN6 (1422438-36-5)

Guidance literature:

Multi-step reaction with 6 steps

1: sodium nitrite; acetic acid / 20 °C

2: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C

3: toluene-4-sulfonic acid / dichloromethane / 20 °C

4: 4-methyl-morpholine / 1-methyl-pyrrolidin-2-one / 120 °C

5: sodium carbonate; potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / acetonitrile / 0.5 h / 130 °C / Microwave irradiation

6: hydrogenchloride / 1,4-dioxane; methanol / 20 °C

With 4-methyl-morpholine; hydrogenchloride; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; toluene-4-sulfonic acid; acetic acid; sodium nitrite; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2015.09.052

Reference yield:

C11H8FN3O2 → C22H21FN6 (1422438-36-5)

Guidance literature:

Multi-step reaction with 7 steps

1: ammonium chloride; iron / ethanol; water / Reflux

2: sodium nitrite; acetic acid / 20 °C

3: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C

4: toluene-4-sulfonic acid / dichloromethane / 20 °C

5: 4-methyl-morpholine / 1-methyl-pyrrolidin-2-one / 120 °C

6: sodium carbonate; potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / acetonitrile / 0.5 h / 130 °C / Microwave irradiation

7: hydrogenchloride / 1,4-dioxane; methanol / 20 °C

With 4-methyl-morpholine; hydrogenchloride; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; iron; sodium carbonate; ammonium chloride; toluene-4-sulfonic acid; acetic acid; sodium nitrite; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2015.09.052

upstream raw materials:

2-bromo-4-methyl-5-nitropyridine

(4-fluoropyridin-3-yl)boronic acid