(S,S)-3-{4-[3-(4'-{3-[4-(2-carboxy-2-ethoxy-ethyl)-phenoxy]-propyl}-2,2'-bis-trifluoromethyl-biphenyl-4-yl)-propoxy]-phenyl}-2-ethoxy-propionic acid

Base Information

Chemical Name:(S,S)-3-{4-[3-(4'-{3-[4-(2-carboxy-2-ethoxy-ethyl)-phenoxy]-propyl}-2,2'-bis-trifluoromethyl-biphenyl-4-yl)-propoxy]-phenyl}-2-ethoxy-propionic acid
CAS No.:719293-36-4
Molecular Formula:C₄₂H₄₄F₆O₈
Molecular Weight:790.797
Hs Code.:

(S,S)-3-{4-[3-(4'-{3-[4-(2-carboxy-2-ethoxy-ethyl)-phenoxy]-propyl}-2,2'-bis-trifluoromethyl-biphenyl-4-yl)-propoxy]-phenyl}-2-ethoxy-propionic acid

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Chemical Property of (S,S)-3-{4-[3-(4'-{3-[4-(2-carboxy-2-ethoxy-ethyl)-phenoxy]-propyl}-2,2'-bis-trifluoromethyl-biphenyl-4-yl)-propoxy]-phenyl}-2-ethoxy-propionic acid

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Technology Process of (S,S)-3-{4-[3-(4'-{3-[4-(2-carboxy-2-ethoxy-ethyl)-phenoxy]-propyl}-2,2'-bis-trifluoromethyl-biphenyl-4-yl)-propoxy]-phenyl}-2-ethoxy-propionic acid

There total 4 articles about (S,S)-3-{4-[3-(4'-{3-[4-(2-carboxy-2-ethoxy-ethyl)-phenoxy]-propyl}-2,2'-bis-trifluoromethyl-biphenyl-4-yl)-propoxy]-phenyl}-2-ethoxy-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89803-70-3
2,2'-bis(trifluoromethyl)-4,4'-diiodobiphenyl

: 719293-36-4
(S,S)-3-{4-[3-(4'-{3-[4-(2-carboxy-2-ethoxy-ethyl)-phenoxy]-propyl}-2,2'-bis-trifluoromethyl-biphenyl-4-yl)-propoxy]-phenyl}-2-ethoxy-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / palladium diacetate; triphenylphosphine / DMF (N,N-dimethyl-formamide) / 5 h / 110 °C / Heating / reflux

2.1: sodium tetrahydroborate / polyethylene glycol (PEG 400) / 6.5 h / 130 °C

3.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 0 °C

3.2: 6 h

4.1: sodium hydroxide; water / ethanol / 48 h / 20 °C

With sodium hydroxide; sodium tetrahydroborate; water; triethylamine; triphenylphosphine; palladium diacetate; triphenylphosphine; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); polyethylene glycol (PEG 400); ethanol;

Reference yield:

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: 719293-36-4
(S,S)-3-{4-[3-(4'-{3-[4-(2-carboxy-2-ethoxy-ethyl)-phenoxy]-propyl}-2,2'-bis-trifluoromethyl-biphenyl-4-yl)-propoxy]-phenyl}-2-ethoxy-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; sodium nitrite / water; acetic acid / 1 h / 5 °C

1.2: 3 h

2.1: triethylamine / palladium diacetate; triphenylphosphine / DMF (N,N-dimethyl-formamide) / 5 h / 110 °C / Heating / reflux

3.1: sodium tetrahydroborate / polyethylene glycol (PEG 400) / 6.5 h / 130 °C

4.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 0 °C

4.2: 6 h

5.1: sodium hydroxide; water / ethanol / 48 h / 20 °C

With sodium hydroxide; sodium tetrahydroborate; sulfuric acid; water; triethylamine; triphenylphosphine; sodium nitrite; palladium diacetate; triphenylphosphine; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); polyethylene glycol (PEG 400); ethanol; water; acetic acid;

Reference yield:

: 2,2'-bistrifluoromethylbiphenyl-4,4'-diacrylic acid dimethyl ester

: 719293-36-4
(S,S)-3-{4-[3-(4'-{3-[4-(2-carboxy-2-ethoxy-ethyl)-phenoxy]-propyl}-2,2'-bis-trifluoromethyl-biphenyl-4-yl)-propoxy]-phenyl}-2-ethoxy-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / polyethylene glycol (PEG 400) / 6.5 h / 130 °C

2.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 0 °C

2.2: 6 h

3.1: sodium hydroxide; water / ethanol / 48 h / 20 °C

With sodium hydroxide; sodium tetrahydroborate; water; triphenylphosphine; In tetrahydrofuran; polyethylene glycol (PEG 400); ethanol;