N-[(3,4-dimethoxyphenyl)methyl]-2-(1H-indol-3-yl)acetamide

Base Information

• Chemical Name: N-[(3,4-dimethoxyphenyl)methyl]-2-(1H-indol-3-yl)acetamide
• CAS No.: 852414-45-0
• Molecular Formula: C₁₉H₂₀N₂O₃
• Molecular Weight: 324.379
• ChEMBL ID: CHEMBL1455693
• DSSTox Substance ID: DTXSID501325937
• Mol file: 852414-45-0.mol

Synonyms:N-[(3,4-dimethoxyphenyl)methyl]-2-(1H-indol-3-yl)acetamide;MLS001174295;CHEMBL1455693;DTXSID501325937;HMS2869G16;AKOS017031231;852414-45-0;SMR000589211;Z26441178

Chemical Property of N-[(3,4-dimethoxyphenyl)methyl]-2-(1H-indol-3-yl)acetamide

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 324.14739250
• Heavy Atom Count: 24
• Complexity: 417

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)CNC(=O)CC2=CNC3=CC=CC=C32)OC

Technology Process of N-[(3,4-dimethoxyphenyl)methyl]-2-(1H-indol-3-yl)acetamide

There total 1 articles about N-[(3,4-dimethoxyphenyl)methyl]-2-(1H-indol-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

C21H21BrN2O3 (1190599-72-4) → C19H20N2O3 (852414-45-0) + C21H22N2O3 (1190599-75-7) + C21H22N2O3 (877968-85-9) + 7',8'-dimethoxy-10',10a'-dihydro-2'H-spiro[indole-3,1'-pyrrolo[1,2-b]isoquinolin]-3'(5'H)-one

Guidance literature:

With dilauryl peroxide; tri-n-butyl-tin hydride; sodium carbonate; In toluene; at 95 ℃; for 5h; stereoselective reaction;

DOI:10.1016/j.tetlet.2009.07.037

upstream raw materials:

C₂₁H₂₁BrN₂O₃