4-benzyloxy-3,5-dimethylbenzyl bromide

Base Information

• Chemical Name: 4-benzyloxy-3,5-dimethylbenzyl bromide
• CAS No.: 960362-58-7
• Molecular Formula: C₁₆H₁₇BrO
• Molecular Weight: 305.214
• Mol file: 960362-58-7.mol

Synonyms:

Chemical Property of 4-benzyloxy-3,5-dimethylbenzyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzyloxy-3,5-dimethylbenzyl bromide

There total 3 articles about 4-benzyloxy-3,5-dimethylbenzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-benzyloxy-3,5-dimethylbenzyl alcohol (773868-60-3) → 4-benzyloxy-3,5-dimethylbenzyl bromide (960362-58-7)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; for 4h;

Reference yield:

methyl 4-(benzyloxy)-3,5-dimethylbenzoate (773873-94-2) → 4-benzyloxy-3,5-dimethylbenzyl bromide (960362-58-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 74.4 percent / LiAlH₄ / diethyl ether / 12 h

2: 67 percent / triphenylphosphine; carbon tetrabromide / CH₂Cl₂ / 4 h

With lithium aluminium tetrahydride; carbon tetrabromide; triphenylphosphine; In diethyl ether; dichloromethane;

Reference yield:

3,5-dimethyl-4-benzyloxy-benzoic acid (97888-80-7) → 4-benzyloxy-3,5-dimethylbenzyl bromide (960362-58-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / sulfuric acid / 8 h / Heating

2: 74.4 percent / LiAlH₄ / diethyl ether / 12 h

3: 67 percent / triphenylphosphine; carbon tetrabromide / CH₂Cl₂ / 4 h

With lithium aluminium tetrahydride; carbon tetrabromide; sulfuric acid; triphenylphosphine; In diethyl ether; dichloromethane;

upstream raw materials:

4-benzyloxy-3,5-dimethylbenzyl alcohol

methyl 4-(benzyloxy)-3,5-dimethylbenzoate

3,5-dimethyl-4-benzyloxy-benzoic acid

Downstream raw materials:

N-(4'-benzyloxy-3',5'-dimethylbenzyl)-N-tosyl-3,4-dimethoxybenzylamine