5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazole

Base Information

Chemical Name:5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazole
CAS No.:1062295-85-5
Molecular Formula:C₇H₇F₃N₂
Molecular Weight:176.141
Hs Code.:
European Community (EC) Number:675-367-9,870-033-0
DSSTox Substance ID:DTXSID30428076
Wikidata:Q82240854

Synonyms:5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazole;1027617-86-2;1062295-85-5;3-cyclopropyl-5-(trifluoromethyl)-1H-Pyrazole;3-Cyclopropyl-5-trifluoromethyl-1H-pyrazole;5-Cyclopropyl-3-trifluoromethyl-1H-pyrazole;SCHEMBL1667926;SCHEMBL16637163;DTXSID30428076;MFCD03422575;MFCD15143082;STK256645;AKOS000308135;AKOS002160522;3-cyclopropyl-5-trifluoromethylpyrazole;NF-0724;NCGC00330637-01;BB 0260096;CS-0060774;CS-0356427;FT-0769928;EN300-41739;F30515;W18871;AB01324980-02;1H-Pyrazole, 3-cyclopropyl-5-(trifluoromethyl)-;J-517451;F2169-0697;Z336080298

Suppliers and Price of 5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazole

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:176.05613272
Heavy Atom Count:12
Complexity:176

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC1C2=CC(=NN2)C(F)(F)F

Technology Process of 5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazole

There total 3 articles about 5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 30923-69-4
1‐cyclopropyl‐4,4,4‐trifluorobutane‐1,3‐dione

: 1062295-85-5,1027617-86-2
3-cyclopropyl-5-(trifluoromethyl)-1H-pyrazole

Guidance literature:: With hydrazine hydrate; acetic acid; In methanol; Inert atmosphere; Reflux;
DOI:10.1021/acs.jmedchem.5b02010

Reference yield:

: 30923-69-4
1‐cyclopropyl‐4,4,4‐trifluorobutane‐1,3‐dione

: 1062295-85-5,1027617-86-2
3-cyclopropyl-5-(trifluoromethyl)-1H-pyrazole

: 3-cyclopropyl-5-(trifluoromethyl)-1H-pyrazole

Guidance literature:: 1‐cyclopropyl‐4,4,4‐trifluorobutane‐1,3‐dione; With hydrazine; In 1,4-dioxane;

In toluene; Further stages.; Heating;
DOI:10.1016/j.jfluchem.2007.04.029

Reference yield:

: 765-43-5
Cyclopropyl methyl ketone

: 1062295-85-5,1027617-86-2
3-cyclopropyl-5-(trifluoromethyl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium / ethanol / 48 h / 0 - 20 °C / Inert atmosphere

2: hydrazine hydrate; acetic acid / methanol / Inert atmosphere; Reflux

With sodium; hydrazine hydrate; acetic acid; In methanol; ethanol;
DOI:10.1021/acs.jmedchem.5b02010