1-(3,4-dimethylphenyl)-4-methyl-N-{4-[(methylsulfonyl)-amino]phenyl}-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide

Base Information

• Chemical Name: 1-(3,4-dimethylphenyl)-4-methyl-N-{4-[(methylsulfonyl)-amino]phenyl}-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide
• CAS No.: 1588395-98-5
• Molecular Formula: C₂₆H₂₅N₅O₅S₂
• Molecular Weight: 551.647
• Mol file: 1588395-98-5.mol

Synonyms:

Chemical Property of 1-(3,4-dimethylphenyl)-4-methyl-N-{4-[(methylsulfonyl)-amino]phenyl}-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,4-dimethylphenyl)-4-methyl-N-{4-[(methylsulfonyl)-amino]phenyl}-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide

There total 3 articles about 1-(3,4-dimethylphenyl)-4-methyl-N-{4-[(methylsulfonyl)-amino]phenyl}-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 1-(3,4-dimethylphenyl)-4-methyl-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylate 5,5-dioxide (1588396-89-7) → 1-(3,4-dimethylphenyl)-4-methyl-N-{4-[(methylsulfonyl)-amino]phenyl}-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide (1588395-98-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide; water / methanol / 1 h / Reflux

2: thionyl chloride / 1 h / Reflux

3: triethylamine / N,N-dimethyl-formamide / 24 h / 40 °C / Inert atmosphere

With thionyl chloride; water; triethylamine; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm401688h

Reference yield:

C12H11NO6S → 1-(3,4-dimethylphenyl)-4-methyl-N-{4-[(methylsulfonyl)-amino]phenyl}-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide (1588395-98-5)

Guidance literature:

Multi-step reaction with 4 steps

1: methanol / 4 h / Reflux

2: sodium hydroxide; water / methanol / 1 h / Reflux

3: thionyl chloride / 1 h / Reflux

4: triethylamine / N,N-dimethyl-formamide / 24 h / 40 °C / Inert atmosphere

With thionyl chloride; water; triethylamine; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm401688h

Reference yield:

1-(3,4-dimethylphenyl)-4-methyl-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylic acid 5,5-dioxide (1588396-42-2) → 1-(3,4-dimethylphenyl)-4-methyl-N-{4-[(methylsulfonyl)-amino]phenyl}-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide (1588395-98-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 1 h / Reflux

2: triethylamine / N,N-dimethyl-formamide / 24 h / 40 °C / Inert atmosphere

With thionyl chloride; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm401688h

upstream raw materials:

methyl 1-(3,4-dimethylphenyl)-4-methyl-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylate 5,5-dioxide

1-(3,4-dimethylphenyl)-4-methyl-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylic acid 5,5-dioxide