(R)-4-Isopropyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole

Base Information

Chemical Name:(R)-4-Isopropyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole
CAS No.:280755-83-1
Molecular Formula:C₁₅H₁₆N₂O
Molecular Weight:240.305
Hs Code.:
European Community (EC) Number:834-040-2
Nikkaji Number:J1.373.651K
Mol file:280755-83-1.mol

Synonyms:280755-83-1;(R)-4-Isopropyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole;1-[(4R)-4,5-Dihydro-4-isopropyl-2-oxazolyl]isoquinoline;(4R)-2-isoquinolin-1-yl-4-propan-2-yl-4,5-dihydro-1,3-oxazole;(R)-iPr-iQuinox;MFCD31568165;BS-45282;CS-0087539;D81135;1-(4R)-4,5-ihydro-4-sopropyl-2-xazolyl]soquinoline;1-[(4R)-4alpha-Isopropyl-2-oxazoline-2-yl]isoquinoline;Z3064471362;1-[(4R)-4,5-Dihydro-4-isopropyl-2-oxazolyl]isoquinoline, 98%, (99% ee)

Suppliers and Price of (R)-4-Isopropyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Strem Chemicals
1-[(4R)-4,5-Dihydro-4-isopropyl-2-oxazolyl]isoquinoline, 98%, (99% ee)
100mg
$ 140.00

BLDpharm
(R)-4-Isopropyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole 97%(99%ee)
1g
$ 378.00

BLDpharm
(R)-4-Isopropyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole 97%(99%ee)
250mg
$ 128.00

BLDpharm
(R)-4-Isopropyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole 97%(99%ee)
100mg
$ 58.00

BLDpharm
(R)-4-Isopropyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole 97%(99%ee)
50mg
$ 38.00

Total 5 raw suppliers

Chemical Property of (R)-4-Isopropyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole

Chemical Property:

Boiling Point:407.1±18.0 °C(Predicted)
PKA:3.79±0.70(Predicted)
Density:1.18±0.1 g/cm3(Predicted)
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:240.126263138
Heavy Atom Count:18
Complexity:327

Purity/Quality:

97% ^*data from raw suppliers

1-[(4R)-4,5-Dihydro-4-isopropyl-2-oxazolyl]isoquinoline, 98%, (99% ee) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)C1COC(=N1)C2=NC=CC3=CC=CC=C32
Isomeric SMILES:CC(C)[C@@H]1COC(=N1)C2=NC=CC3=CC=CC=C32

Technology Process of (R)-4-Isopropyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole

There total 3 articles about (R)-4-Isopropyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1198-30-7
1-isoquinolinecarbonitrile

: 2026-48-4,473-75-6
(S)-valinol

: 280755-83-1
(S)-4-isopropyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole

Guidance literature:: With zinc(II) chloride; In chlorobenzene; at 140 ℃; for 48h; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.orglett.5b00863

Reference yield:

: 140706-11-2
Naphthalene-1-carboxylic acid ((S)-1-hydroxymethyl-2-methyl-propyl)-amide

: 280755-83-1
(S)-4-isopropyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole

Guidance literature:: With dmap; triethylamine; p-toluenesulfonyl chloride; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/acs.orglett.6b03410

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 280755-83-1
(S)-4-isopropyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine / dichloromethane / 0.25 h / Inert atmosphere

1.2: 0.5 h / -15 - 20 °C / Inert atmosphere

1.3: 1 h / -15 - 20 °C / Inert atmosphere

2.1: triethylamine; dmap; p-toluenesulfonyl chloride / dichloromethane / 3 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; dmap; triethylamine; p-toluenesulfonyl chloride; In dichloromethane;
DOI:10.1021/acs.orglett.6b03410