ethyl 2-amino-5-(2,2,2-trifluoroethyl)thiophene-3-carboxylate

Base Information

• Chemical Name: ethyl 2-amino-5-(2,2,2-trifluoroethyl)thiophene-3-carboxylate
• CAS No.: 1160720-50-2
• Molecular Formula: C₉H₁₀F₃NO₂S
• Molecular Weight: 253.245
• Mol file: 1160720-50-2.mol

Synonyms:

Chemical Property of ethyl 2-amino-5-(2,2,2-trifluoroethyl)thiophene-3-carboxylate

Chemical Property:

• Boiling Point: 297.0±40.0 °C(Predicted)
• Density: 1.370±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-Amino-5-(2,2,2-trifluoroethyl)thiophene-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-amino-5-(2,2,2-trifluoroethyl)thiophene-3-carboxylate

There total 1 articles about ethyl 2-amino-5-(2,2,2-trifluoroethyl)thiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4,4-trifluorobutanal (406-87-1) + ethyl 2-cyanoacetate (105-56-6) → ethyl 2-amino-5-(2,2,2-trifluoroethyl)thiophene-3-carboxylate (1160720-50-2)

Guidance literature:

With sulfur; triethylamine; In isopropyl methanesulfonate; for 1.5h;

Reference yield:

ethyl 2-amino-5-(2,2,2-trifluoroethyl)thiophene-3-carboxylate (1160720-50-2) → 4-(7-(3-nitrobenzyl)-2,7-diazaspiro[4.4]nonan-2-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine

Guidance literature:

Multi-step reaction with 5 steps

1: ammonium formate / formamide / 18 h / 135 - 140 °C / Inert atmosphere

2: thionyl chloride / N,N-dimethyl-formamide / 7 h / 75 - 80 °C

3: sodium carbonate / acetonitrile / 3 h / 90 °C

4: hydrogenchloride / methanol / 0.5 h / 20 - 25 °C

5: sodium cyanoborohydride; acetic acid / methanol / 1 h / 50 °C

With hydrogenchloride; thionyl chloride; ammonium formate; sodium cyanoborohydride; sodium carbonate; acetic acid; In methanol; formamide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

ethyl 2-amino-5-(2,2,2-trifluoroethyl)thiophene-3-carboxylate (1160720-50-2) → 3-((7-(6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)-2,7-diazaspiro[4 .4]nonan-2-yl)methyl)aniline

Guidance literature:

Multi-step reaction with 6 steps

1: ammonium formate / formamide / 18 h / 135 - 140 °C / Inert atmosphere

2: thionyl chloride / N,N-dimethyl-formamide / 7 h / 75 - 80 °C

3: sodium carbonate / acetonitrile / 3 h / 90 °C

4: hydrogenchloride / methanol / 0.5 h / 20 - 25 °C

5: sodium cyanoborohydride; acetic acid / methanol / 1 h / 50 °C

6: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h / 24 - 29 °C / 775.74 Torr

With hydrogenchloride; thionyl chloride; palladium 10% on activated carbon; hydrogen; ammonium formate; sodium cyanoborohydride; sodium carbonate; acetic acid; In methanol; formamide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

4,4,4-trifluorobutanal

ethyl 2-cyanoacetate

Downstream raw materials:

4-chloro-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine