3-(2-((4-((2-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)propylcarbamoyl)-4-ethynylphenyl)ethynyl)phenyl)-ethenyl)-5-ethynylbenzamido)propyl 2-cyanoethyl diisopropylphosphoramidite

Base Information

Chemical Name:3-(2-((4-((2-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)propylcarbamoyl)-4-ethynylphenyl)ethynyl)phenyl)-ethenyl)-5-ethynylbenzamido)propyl 2-cyanoethyl diisopropylphosphoramidite
CAS No.:1352946-70-3
Molecular Formula:C₆₄H₆₃N₄O₇P
Molecular Weight:1031.2
Hs Code.:

3-(2-((4-((2-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)propylcarbamoyl)-4-ethynylphenyl)ethynyl)phenyl)-ethenyl)-5-ethynylbenzamido)propyl 2-cyanoethyl diisopropylphosphoramidite

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Chemical Property of 3-(2-((4-((2-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)propylcarbamoyl)-4-ethynylphenyl)ethynyl)phenyl)-ethenyl)-5-ethynylbenzamido)propyl 2-cyanoethyl diisopropylphosphoramidite

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Technology Process of 3-(2-((4-((2-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)propylcarbamoyl)-4-ethynylphenyl)ethynyl)phenyl)-ethenyl)-5-ethynylbenzamido)propyl 2-cyanoethyl diisopropylphosphoramidite

There total 6 articles about 3-(2-((4-((2-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)propylcarbamoyl)-4-ethynylphenyl)ethynyl)phenyl)-ethenyl)-5-ethynylbenzamido)propyl 2-cyanoethyl diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352946-67-8
6,6'-(1,4-phenylenebis(ethyne-2,1-diyl))bis-(3-bromo-N-(3-tert-butyldimethylsilyloxy)propyl)benzamide

: 1352946-70-3
3-(2-((4-((2-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)propylcarbamoyl)-4-ethynylphenyl)ethynyl)phenyl)-ethenyl)-5-ethynylbenzamido)propyl 2-cyanoethyl diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 4 h / 50 °C / Inert atmosphere

2: triethylamine hydrofluoride / tetrahydrofuran / 6 h / 20 °C

3: pyridine / 3 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine hydrofluoride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201105095

Reference yield:

: 1352946-71-4
6,6'-(1,4-phenylenebis(ethyne-2,1-diyl))bis-(N-(3-tert-butyldimethylsilyloxy)propyl)-3-((trimethylsilyl)ethynyl)benzamide

: 1352946-70-3
3-(2-((4-((2-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)propylcarbamoyl)-4-ethynylphenyl)ethynyl)phenyl)-ethenyl)-5-ethynylbenzamido)propyl 2-cyanoethyl diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine hydrofluoride / tetrahydrofuran / 6 h / 20 °C

2: pyridine / 3 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With pyridine; triethylamine hydrofluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201105095

Reference yield:

: 1352946-66-7
5-bromo-N-(3-(tert-butyldimethylsilyloxy)propyl)-2-iodobenzamide

: 1352946-70-3
3-(2-((4-((2-(3-(bis(4-methoxyphenyl)(phenyl)methoxy)propylcarbamoyl)-4-ethynylphenyl)ethynyl)phenyl)-ethenyl)-5-ethynylbenzamido)propyl 2-cyanoethyl diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 5 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 6 h / 50 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 4 h / 50 °C / Inert atmosphere

3: triethylamine hydrofluoride / tetrahydrofuran / 6 h / 20 °C

4: pyridine / 3 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine hydrofluoride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1: Sonogashira coupling;
DOI:10.1002/anie.201105095