(S)-methyl 4-((2S,3S,4R,5R,6R)-4,5-di(benzyloxy)-6-((benzyloxy)-methyl)-3-hydroxytetrahydro-2H-pyran-2yl)-2-((tert-butoxycarbonyl)amino)butanoate

Base Information

Chemical Name:(S)-methyl 4-((2S,3S,4R,5R,6R)-4,5-di(benzyloxy)-6-((benzyloxy)-methyl)-3-hydroxytetrahydro-2H-pyran-2yl)-2-((tert-butoxycarbonyl)amino)butanoate
CAS No.:1442044-21-4
Molecular Formula:C₃₇H₄₇NO₉
Molecular Weight:649.781
Hs Code.:

(S)-methyl 4-((2S,3S,4R,5R,6R)-4,5-di(benzyloxy)-6-((benzyloxy)-methyl)-3-hydroxytetrahydro-2H-pyran-2yl)-2-((tert-butoxycarbonyl)amino)butanoate

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Chemical Property of (S)-methyl 4-((2S,3S,4R,5R,6R)-4,5-di(benzyloxy)-6-((benzyloxy)-methyl)-3-hydroxytetrahydro-2H-pyran-2yl)-2-((tert-butoxycarbonyl)amino)butanoate

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Technology Process of (S)-methyl 4-((2S,3S,4R,5R,6R)-4,5-di(benzyloxy)-6-((benzyloxy)-methyl)-3-hydroxytetrahydro-2H-pyran-2yl)-2-((tert-butoxycarbonyl)amino)butanoate

There total 5 articles about (S)-methyl 4-((2S,3S,4R,5R,6R)-4,5-di(benzyloxy)-6-((benzyloxy)-methyl)-3-hydroxytetrahydro-2H-pyran-2yl)-2-((tert-butoxycarbonyl)amino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1442044-34-9
C₃₇H₄₅NO₉

: 1442044-21-4
(S)-methyl 4-((2S,3S,4R,5R,6R)-4,5-di(benzyloxy)-6-((benzyloxy)-methyl)-3-hydroxytetrahydro-2H-pyran-2yl)-2-((tert-butoxycarbonyl)amino)butanoate

Guidance literature:: With sodium tetrahydroborate; In methanol; at -10 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jo401044x

Reference yield:

: 1072440-16-4
(2R)-methyl 4-((3S,4R,5R,6R)-4,5-bis(benzyloxy)-6-(benzyloxymethyl)-3-hydroxytetrahydro-2H-pyran-2-yl)-2-(tert-butoxycarbonylamino)butanoate

: 1442044-21-4
(S)-methyl 4-((2S,3S,4R,5R,6R)-4,5-di(benzyloxy)-6-((benzyloxy)-methyl)-3-hydroxytetrahydro-2H-pyran-2yl)-2-((tert-butoxycarbonyl)amino)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 12 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 1 h / -10 °C / Inert atmosphere

With sodium tetrahydroborate; Dess-Martin periodane; In methanol; dichloromethane;
DOI:10.1021/jo401044x

Reference yield:

: 1072440-22-2
(2S,6S,7R,8R,9R,Z)-methyl 7,8,10-tris(benzyloxy)-2-(tert-butoxycarbonylamino)-6,9-dihydroxydec-4-enoate

: 1442044-21-4
(S)-methyl 4-((2S,3S,4R,5R,6R)-4,5-di(benzyloxy)-6-((benzyloxy)-methyl)-3-hydroxytetrahydro-2H-pyran-2yl)-2-((tert-butoxycarbonyl)amino)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: mercury(II) trifluoroacetate

2: Dess-Martin periodane / dichloromethane / 12 h / 20 °C / Inert atmosphere

3: sodium tetrahydroborate / methanol / 1 h / -10 °C / Inert atmosphere

With sodium tetrahydroborate; mercury(II) trifluoroacetate; Dess-Martin periodane; In methanol; dichloromethane;
DOI:10.1021/jo401044x