Technology Process of (E)-5-((tert-butyldiphenylsilyl)oxy)-4-methylpent-3-en-2-one
There total 4 articles about (E)-5-((tert-butyldiphenylsilyl)oxy)-4-methylpent-3-en-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic anhydride; pyridinium chlorochromate / dichloromethane / 1 h / 20 °C / Molecular sieve
2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
2.2: 12 h / 20 °C
3.1: isopropylmagnesium chloride / tetrahydrofuran / 1.5 h / 0 - 20 °C
4.1: tetrahydrofuran; diethyl ether / 1 h / 0 °C
With
isopropylmagnesium chloride; acetic anhydride; sodium hydride; pyridinium chlorochromate;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1002/chem.201200694
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Reflux
2.1: diethyl ether / 1 h / 0 °C
3.1: acetic anhydride; pyridinium chlorochromate / dichloromethane / 1 h / 20 °C / Molecular sieve
4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
4.2: 12 h / 20 °C
5.1: isopropylmagnesium chloride / tetrahydrofuran / 1.5 h / 0 - 20 °C
6.1: tetrahydrofuran; diethyl ether / 1 h / 0 °C
With
isopropylmagnesium chloride; acetic anhydride; sodium hydride; pyridinium chlorochromate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1002/chem.201200694
- Guidance literature:
-
Multi-step reaction with 2 steps
1: isopropylmagnesium chloride / tetrahydrofuran / 1.5 h / 0 - 20 °C
2: tetrahydrofuran; diethyl ether / 1 h / 0 °C
With
isopropylmagnesium chloride;
In
tetrahydrofuran; diethyl ether;
DOI:10.1002/chem.201200694