5-((3aS,6R,6aR)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid {2-[2-(4-{1-[1-(3-amino-phenyl)-cyclohexyl]-piperidin-2-yl}-butylcarbamoyl)-ethyldisulfanyl]-ethyl}-amide

Base Information

Chemical Name:5-((3aS,6R,6aR)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid {2-[2-(4-{1-[1-(3-amino-phenyl)-cyclohexyl]-piperidin-2-yl}-butylcarbamoyl)-ethyldisulfanyl]-ethyl}-amide
CAS No.:126308-44-9
Molecular Formula:C₃₆H₅₈N₆O₃S₃
Molecular Weight:719.093
Hs Code.:

5-((3aS,6R,6aR)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid {2-[2-(4-{1-[1-(3-amino-phenyl)-cyclohexyl]-piperidin-2-yl}-butylcarbamoyl)-ethyldisulfanyl]-ethyl}-amide

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Chemical Property of 5-((3aS,6R,6aR)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid {2-[2-(4-{1-[1-(3-amino-phenyl)-cyclohexyl]-piperidin-2-yl}-butylcarbamoyl)-ethyldisulfanyl]-ethyl}-amide

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Technology Process of 5-((3aS,6R,6aR)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid {2-[2-(4-{1-[1-(3-amino-phenyl)-cyclohexyl]-piperidin-2-yl}-butylcarbamoyl)-ethyldisulfanyl]-ethyl}-amide

There total 8 articles about 5-((3aS,6R,6aR)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid {2-[2-(4-{1-[1-(3-amino-phenyl)-cyclohexyl]-piperidin-2-yl}-butylcarbamoyl)-ethyldisulfanyl]-ethyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 126308-43-8
3-{1-[2-(4-Amino-butyl)-piperidin-1-yl]-cyclohexyl}-phenylamine

: 114616-18-1
Sodium; 2,5-dioxo-1-(3-{2-[5-((3aS,6R,6aR)-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethyldisulfanyl}-propionyloxy)-pyrrolidine-3-sulfonate

: 126308-44-9
5-((3aS,6R,6aR)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid {2-[2-(4-{1-[1-(3-amino-phenyl)-cyclohexyl]-piperidin-2-yl}-butylcarbamoyl)-ethyldisulfanyl]-ethyl}-amide

Guidance literature:: In tetrahydrofuran; water; Ambient temperature;
DOI:10.1016/S0040-4039(01)80756-5

Reference yield:

: 126308-37-0
1-[1-(3-Bromo-phenyl)-cyclohexyl]-piperidine

: 126308-44-9
5-((3aS,6R,6aR)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid {2-[2-(4-{1-[1-(3-amino-phenyl)-cyclohexyl]-piperidin-2-yl}-butylcarbamoyl)-ethyldisulfanyl]-ethyl}-amide

Guidance literature:: Multi-step reaction with 8 steps

2: 97 percent / diethyl ether / 0 °C

4: 93 percent / LiAlH₄ / tetrahydrofuran / 0 °C

5: 1.) 9-BBN; 2.) H₂O₂, NaOH / 1.) THF, room temp.; 2.) H₂O, 0 deg C

6: 77 percent / HN₃, PPh₃, DEAD / CH₂Cl₂ / Ambient temperature

7: 95 percent / H₂ / PtO₂ / ethyl acetate

8: 77 percent / H₂O; tetrahydrofuran / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; tris-(2-chloro-ethyl)-amine; hydrogen; dihydrogen peroxide; triphenylphosphine; diethylazodicarboxylate; platinum(IV) oxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; ethyl acetate;
DOI:10.1016/S0040-4039(01)80756-5

Reference yield:

: 126346-73-4
3-[1-(2-But-3-enyl-piperidin-1-yl)-cyclohexyl]-phenylamine

: 126308-44-9
5-((3aS,6R,6aR)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid {2-[2-(4-{1-[1-(3-amino-phenyl)-cyclohexyl]-piperidin-2-yl}-butylcarbamoyl)-ethyldisulfanyl]-ethyl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 9-BBN; 2.) H₂O₂, NaOH / 1.) THF, room temp.; 2.) H₂O, 0 deg C

2: 77 percent / HN₃, PPh₃, DEAD / CH₂Cl₂ / Ambient temperature

3: 95 percent / H₂ / PtO₂ / ethyl acetate

4: 77 percent / H₂O; tetrahydrofuran / Ambient temperature

With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; tris-(2-chloro-ethyl)-amine; hydrogen; dihydrogen peroxide; triphenylphosphine; diethylazodicarboxylate; platinum(IV) oxide; In tetrahydrofuran; dichloromethane; water; ethyl acetate;
DOI:10.1016/S0040-4039(01)80756-5