C₁₆H₁₃ClFN₃O₂

Base Information

Chemical Name:C₁₆H₁₃ClFN₃O₂
CAS No.:1403226-62-9
Molecular Formula:C₁₆H₁₃ClFN₃O₂
Molecular Weight:333.75
Hs Code.:

C<sub>16</sub>H<sub>13</sub>ClFN<sub>3</sub>O<sub>2</sub>

Synonyms:

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Chemical Property of C₁₆H₁₃ClFN₃O₂

Chemical Property:

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Technology Process of C₁₆H₁₃ClFN₃O₂

There total 9 articles about C₁₆H₁₃ClFN₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-{2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetohydrazide

: 1403226-62-9
C₁₆H₁₃ClFN₃O₂

Guidance literature:: With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1002/cmdc.201200272

Reference yield:

: 1175086-67-5
2-[(2-chloro-6-fluorophenyl)amino]-5-methylbenzeneacetic acid methyl ester

: 1403226-62-9
C₁₆H₁₃ClFN₃O₂

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 1.5 h / Reflux

2: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 °C / Inert atmosphere

With hydrazine hydrate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol;
DOI:10.1002/cmdc.201200272

Reference yield:

: 2941-78-8
2-Amino-5-methylbenzoic acid

: 1403226-62-9
C₁₆H₁₃ClFN₃O₂

Guidance literature:: Multi-step reaction with 8 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(II) acetate monohydrate / 1,4-dioxane / 25 °C

2: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

3: pyridine; thionyl chloride / tetrahydrofuran / 0 - 5 °C

4: dimethyl sulfoxide / 1.5 h / Inert atmosphere

5: water; barium(II) hydroxide / 1,4-dioxane / 30 h / Reflux; Inert atmosphere

6: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

7: hydrazine hydrate / ethanol / 1.5 h / Reflux

8: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 °C / Inert atmosphere

With pyridine; dmap; thionyl chloride; hydrazine hydrate; dimethylsulfide borane complex; water; copper(II) acetate monohydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole; barium(II) hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide; 1: |Chan-Lam Coupling;
DOI:10.1002/cmdc.201200272