5-(3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridin-6-yl)oxazole

Base Information

Chemical Name:5-(3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridin-6-yl)oxazole
CAS No.:1200130-25-1
Molecular Formula:C₂₅H₂₃N₅O
Molecular Weight:409.491
Hs Code.:

Synonyms:

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Chemical Property of 5-(3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridin-6-yl)oxazole

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Technology Process of 5-(3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridin-6-yl)oxazole

There total 9 articles about 5-(3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridin-6-yl)oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1200130-82-0
6-bromo-4-iodonicotinic acid

: 1200130-25-1
5-(3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridin-6-yl)oxazole

Guidance literature:: Multi-step reaction with 5 steps

1: diphenylphosphoranyl azide; triethylamine / toluene / 3 h / 110 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: potassium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; acetonitrile / 4 h / 90 °C

4: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

5: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; acetonitrile / 0.5 h / 130 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; diphenylphosphoranyl azide; sodium hexamethyldisilazane; sodium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; toluene; acetonitrile; 5: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.jmedchem.5b00464

Reference yield:

: 1200130-83-1
tert-butyl (6-bromo-4-iodopyridin-3-yl)carbamate

: 1200130-25-1
5-(3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridin-6-yl)oxazole

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: potassium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; acetonitrile / 4 h / 90 °C

3: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; acetonitrile / 0.5 h / 130 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; sodium hexamethyldisilazane; sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile; 4: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.jmedchem.5b00464

Reference yield:

: 1200130-84-2
6-bromo-4-iodopyridin-3-ylamine

: 1200130-25-1
5-(3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridin-6-yl)oxazole

Guidance literature:: Multi-step reaction with 3 steps

1: potassium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; acetonitrile / 4 h / 90 °C

2: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; acetonitrile / 0.5 h / 130 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; sodium hexamethyldisilazane; sodium carbonate; In tetrahydrofuran; water; acetonitrile; 3: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.jmedchem.5b00464