sodium 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1R,4S)-4-hydroxy-4-(((S)-tetrahydrofuran-3-yloxy)methyl)cyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

Base Information

Chemical Name:sodium 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1R,4S)-4-hydroxy-4-(((S)-tetrahydrofuran-3-yloxy)methyl)cyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate
CAS No.:1314795-25-9
Molecular Formula:C₃₀H₄₂NO₆S*Na
Molecular Weight:567.722
Hs Code.:

sodium 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1R,4S)-4-hydroxy-4-(((S)-tetrahydrofuran-3-yloxy)methyl)cyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

Synonyms:

Suppliers and Price of sodium 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1R,4S)-4-hydroxy-4-(((S)-tetrahydrofuran-3-yloxy)methyl)cyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of sodium 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1R,4S)-4-hydroxy-4-(((S)-tetrahydrofuran-3-yloxy)methyl)cyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of sodium 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1R,4S)-4-hydroxy-4-(((S)-tetrahydrofuran-3-yloxy)methyl)cyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

There total 10 articles about sodium 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1R,4S)-4-hydroxy-4-(((S)-tetrahydrofuran-3-yloxy)methyl)cyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1314795-23-7
methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4r)-4-methyl-N-(1-oxaspiro[2.5]octan-6-yl)cyclohexanecarboxamido)thiophene-2-carboxylate

: 86087-23-2,84921-89-1,864447-89-2
(S)-3-hydroxytetyrahydrofurane

: 1314795-25-9
sodium 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1R,4S)-4-hydroxy-4-(((S)-tetrahydrofuran-3-yloxy)methyl)cyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 75 ℃; for 60h;
DOI:10.1021/jm401420j

Reference yield:

: 934-67-8,4331-54-8,13064-83-0
trans-4-methylcyclohexanecarboxylic acid

: 1314795-25-9
sodium 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1R,4S)-4-hydroxy-4-(((S)-tetrahydrofuran-3-yloxy)methyl)cyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane; N,N-dimethyl-formamide / 3 h / 0 - 20 °C

2.1: pyridine / toluene / 16 h / Reflux

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -75 - -60 °C

3.2: 3 h / -78 °C

4.1: copper(l) iodide; triethylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / N,N-dimethyl-formamide / 12 h / 60 °C / Inert atmosphere

5.1: hydrogenchloride / tetrahydrofuran; water / 12 h / 40 °C

6.1: sodium hydride / dimethyl sulfoxide / 0.25 h / 20 °C

6.2: 3 h / 20 °C

7.1: sodium hydride / tetrahydrofuran; mineral oil / 60 h / 0 - 75 °C

With pyridine; hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; n-butyllithium; sodium hydride; triethylamine; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm401420j

Reference yield:

: 55930-23-9
trans-4-methylcyclohexanecarbonyl chloride

: 1314795-25-9
sodium 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1R,4S)-4-hydroxy-4-(((S)-tetrahydrofuran-3-yloxy)methyl)cyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / toluene / 16 h / Reflux

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -75 - -60 °C

2.2: 3 h / -78 °C

3.1: copper(l) iodide; triethylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / N,N-dimethyl-formamide / 12 h / 60 °C / Inert atmosphere

4.1: hydrogenchloride / tetrahydrofuran; water / 12 h / 40 °C

5.1: sodium hydride / dimethyl sulfoxide / 0.25 h / 20 °C

5.2: 3 h / 20 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 60 h / 0 - 75 °C

With pyridine; hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; n-butyllithium; sodium hydride; triethylamine; diisopropylamine; In tetrahydrofuran; hexane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm401420j