(R)-[(S)-1-(4-Hydroxy-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid isopropyl ester

Base Information

• Chemical Name: (R)-[(S)-1-(4-Hydroxy-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid isopropyl ester
• CAS No.: 128640-19-7
• Molecular Formula: C₁₇H₂₀NO₅P
• Molecular Weight: 349.323
• Mol file: 128640-19-7.mol

Synonyms:

Chemical Property of (R)-[(S)-1-(4-Hydroxy-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid isopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-[(S)-1-(4-Hydroxy-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid isopropyl ester

There total 4 articles about (R)-[(S)-1-(4-Hydroxy-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isopropyl phenylphosphinate (13336-50-0) → (R)-[(R)-1-(4-Hydroxy-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid isopropyl ester (128640-19-7,128640-42-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NEt₃ / dimethylformamide / 1) 0 deg C, 2) rt

2: 2) H₂O / 1) DMF, rt, 10 h

With water; triethylamine; In N,N-dimethyl-formamide;

Reference yield:

isopropyl phenylphosphinate (13336-50-0) → (R)-[(S)-1-(4-Hydroxy-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid isopropyl ester (128640-19-7,128640-42-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NEt₃ / dimethylformamide / 1) 0 deg C, 2) rt

2: 2) H₂O / 1) DMF, rt, 10 h

With water; triethylamine; In N,N-dimethyl-formamide;

Reference yield:

(E)-1-(4-hydroxyphenyl)-2-nitroethene (22568-49-6) + C12H21O2PSi → (R)-[(R)-1-(4-Hydroxy-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid isopropyl ester (128640-19-7,128640-42-6) + (R)-[(S)-1-(4-Hydroxy-phenyl)-2-nitro-ethyl]-phenyl-phosphinic acid isopropyl ester (128640-19-7,128640-42-6)

Guidance literature:

With water; Multistep reaction. Title compound not separated from byproducts; 1) DMF, rt, 10 h;

upstream raw materials:

(E)-1-(4-hydroxyphenyl)-2-nitroethene

isopropyl phenylphosphinate

Refernces