ethyl (2,5-dimethylbenzoyl)pyruvate

Base Information

• Chemical Name: ethyl (2,5-dimethylbenzoyl)pyruvate
• CAS No.: 57961-50-9
• Molecular Formula: C₁₄H₁₆O₄
• Molecular Weight: 248.279
• Mol file: 57961-50-9.mol

Synonyms:

Chemical Property of ethyl (2,5-dimethylbenzoyl)pyruvate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (2,5-dimethylbenzoyl)pyruvate

There total 2 articles about ethyl (2,5-dimethylbenzoyl)pyruvate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2,5-dimethylphenyl)-1-ethanone (2142-73-6) + oxalic acid diethyl ester (95-92-1) → ethyl (2,5-dimethylbenzoyl)pyruvate (57961-50-9)

Guidance literature:

With sodium ethanolate; In ethanol;

Reference yield:

→ ethyl (2,5-dimethylbenzoyl)pyruvate (57961-50-9)

Guidance literature:

NaOEt, /BRN= 42139/, Ethyloxalate, H2SO4;

DOI:10.1248/cpb.23.2239

Reference yield:

ethyl (2,5-dimethylbenzoyl)pyruvate (57961-50-9) → 2-(2,5-dimethylphenyl)thieno[2,3-b]quinoxaline

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 1 h / Heating

2: phosphorus pentasulphide / pyridine / 6 h / Heating

With diphosphorus pentasulfide; acetic acid; In pyridine;

upstream raw materials:

1-(2,5-dimethylphenyl)-1-ethanone

oxalic acid diethyl ester

Downstream raw materials:

6-[2-(2,5-dimethyl-phenyl)-2-oxo-ethyl]-3-thioxo-3,4-dihydro-2H-[1,2,4]triazin-5-one

3-[2-(2,5-dimethyl-phenyl)-2-oxo-ethyl]-1H-quinoxalin-2-one

2-(2,5-dimethylphenyl)furo[2,3-b]quinoxaline

C₁₉H₁₉N₅O₂

Refernces

• 1、 Oka,Omura,Miyake,et al.. "Studies on the syntheses of N heterocyclic compounds. XXV. Syntheses of pyrido[3,4 d]pyridazine derivatives". . p. 2239 - 2250. Retrieved 2007/10/05.