N^α-(tert-butyloxycarbonyl)-DL-hexafluorovaline

Base Information

• Chemical Name: N^α-(tert-butyloxycarbonyl)-DL-hexafluorovaline
• CAS No.: 107496-46-8
• Molecular Formula: C₁₀H₁₃F₆NO₄
• Molecular Weight: 325.208
• Mol file: 107496-46-8.mol

Synonyms:

Chemical Property of N^α-(tert-butyloxycarbonyl)-DL-hexafluorovaline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-(tert-butyloxycarbonyl)-DL-hexafluorovaline

There total 6 articles about N^α-(tert-butyloxycarbonyl)-DL-hexafluorovaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

di-tert-butyl dicarbonate (24424-99-5) + (RS)-hexafluorovaline (16063-80-2) → Nα-(tert-butyloxycarbonyl)-DL-hexafluorovaline (107496-46-8,1098184-03-2)

Guidance literature:

di-tert-butyl dicarbonate; (RS)-hexafluorovaline; With sodium carbonate; In 1,4-dioxane; water; at 0 - 20 ℃; for 12h;

With citric acid; In water; pH=> 4;

Reference yield:

DL-hexafluorovaline benzyl ester (107496-45-7) → Nα-(tert-butyloxycarbonyl)-DL-hexafluorovaline (107496-46-8,1098184-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / H₂ / Pd / methanol

2: 1.9 g / 1N NaOH / 2-methyl-propan-2-ol / 48 h / Ambient temperature

With sodium hydroxide; hydrogen; palladium; In methanol; tert-butyl alcohol;

DOI:10.1021/jm00389a021

Reference yield:

benzyl 4,4,4-trifluoro-3-(trifluoromethyl)but-2-enoate (107496-44-6) → Nα-(tert-butyloxycarbonyl)-DL-hexafluorovaline (107496-46-8,1098184-03-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / NH₃ (liq.) / diethyl ether / a) -80 deg C, 45 min, b) RT, overnight

2: 78 percent / H₂ / Pd / methanol

3: 1.9 g / 1N NaOH / 2-methyl-propan-2-ol / 48 h / Ambient temperature

With sodium hydroxide; ammonia; hydrogen; palladium; In methanol; diethyl ether; tert-butyl alcohol;

DOI:10.1021/jm00389a021

upstream raw materials:

tert-butyldicarbonate

(RS)-hexafluorovaline

di-tert-butyl dicarbonate

ethyl 4,4,4-trifluoro-3-(trifluoromethyl)crotonate

Downstream raw materials:

C₁₀H₁₃F₆NO₄