-(R)-(+)-α-methylbenzylamine

Base Information

Chemical Name:-(R)-(+)-α-methylbenzylamine
CAS No.:136237-70-2
Molecular Formula:C₁₉H₂₈N₂O₃
Molecular Weight:332.443
Hs Code.:

<N-(tert-butyloxycarbonyl)-trans-2-aminocyclopentanecarbonyl>-(R)-(+)-α-methylbenzylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of -(R)-(+)-α-methylbenzylamine

Chemical Property:

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Technology Process of -(R)-(+)-α-methylbenzylamine

There total 1 articles about -(R)-(+)-α-methylbenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 136315-71-4
(±)-trans-2-((tert-butoxycarbonyl)amino)cyclopentanecarboxylic acid

: 136237-70-2,136315-75-8
-(R)-(+)-α-methylbenzylamine

Guidance literature:: With 4-methyl-morpholine; isobutyl chloroformate; Yield given. Multistep reaction; 1) THF, -15 deg C, 10 min, 2) THF, a) -15 deg C, 1 h, b) r.t., 4 h;
DOI:10.1021/jo00023a033

Reference yield:

: 136237-70-2,136315-75-8
-(R)-(+)-α-methylbenzylamine

: 136315-75-8
-(R)-(+)-α-methylbenzylamine

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 2 h / Ambient temperature

2: tetrahydrofuran / 0.5 h / Ambient temperature

With trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1021/jo00023a033

Reference yield:

: 136237-70-2,136315-75-8
-(R)-(+)-α-methylbenzylamine

: 136315-66-7
N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-trans-(1S,2S)-2-aminocyclopentanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / 2 h / Ambient temperature

2: 71 percent / conc. HCl / 8 h / Heating

3: SOCl₂ / 1) r.t., overnight, 2) reflux, 4 h

4: N-hydroxybenzotriazole, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / pH 6 (Et₃N), 1) -30 deg C, 1 h, 2) r.t., 2 h

With hydrogenchloride; thionyl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jo00023a033