tert-Butyl-[(1S,2R,3R)-2-(3-methoxy-2-methoxymethoxy-6-methylsulfanylmethoxymethyl-phenyl)-3-(2-methyl-propane-2-sulfonyl)-cyclohexyloxy]-dimethyl-silane

Base Information

Chemical Name:tert-Butyl-[(1S,2R,3R)-2-(3-methoxy-2-methoxymethoxy-6-methylsulfanylmethoxymethyl-phenyl)-3-(2-methyl-propane-2-sulfonyl)-cyclohexyloxy]-dimethyl-silane
CAS No.:76504-35-3
Molecular Formula:C₂₈H₅₀O₇S₂Si
Molecular Weight:590.918
Hs Code.:

tert-Butyl-[(1S,2R,3R)-2-(3-methoxy-2-methoxymethoxy-6-methylsulfanylmethoxymethyl-phenyl)-3-(2-methyl-propane-2-sulfonyl)-cyclohexyloxy]-dimethyl-silane

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Chemical Property of tert-Butyl-[(1S,2R,3R)-2-(3-methoxy-2-methoxymethoxy-6-methylsulfanylmethoxymethyl-phenyl)-3-(2-methyl-propane-2-sulfonyl)-cyclohexyloxy]-dimethyl-silane

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Technology Process of tert-Butyl-[(1S,2R,3R)-2-(3-methoxy-2-methoxymethoxy-6-methylsulfanylmethoxymethyl-phenyl)-3-(2-methyl-propane-2-sulfonyl)-cyclohexyloxy]-dimethyl-silane

There total 1 articles about tert-Butyl-[(1S,2R,3R)-2-(3-methoxy-2-methoxymethoxy-6-methylsulfanylmethoxymethyl-phenyl)-3-(2-methyl-propane-2-sulfonyl)-cyclohexyloxy]-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 75534-22-4
3-(tert-butyldimethylsiloxy)-1-cyclohexenyl tert-butyl sulfone

: C₁₂H₁₇LiO₄S

: 76504-35-3
tert-Butyl-[(1S,2R,3R)-2-(3-methoxy-2-methoxymethoxy-6-methylsulfanylmethoxymethyl-phenyl)-3-(2-methyl-propane-2-sulfonyl)-cyclohexyloxy]-dimethyl-silane

Guidance literature:: In tetrahydrofuran; hexane; Product distribution; variations of solvents, examination of further aryl lithium reagents and γ-silyloxy-α,β-unsaturated sulfones;
DOI:10.1016/S0040-4039(00)92786-2

Reference yield:

: 76504-35-3
tert-Butyl-[(1S,2R,3R)-2-(3-methoxy-2-methoxymethoxy-6-methylsulfanylmethoxymethyl-phenyl)-3-(2-methyl-propane-2-sulfonyl)-cyclohexyloxy]-dimethyl-silane

: (1S,2R,3R)-2-(3-Methoxy-2-methoxymethoxy-6-methylsulfanylmethoxymethyl-phenyl)-3-(2-methyl-propane-2-sulfonyl)-cyclohexanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 24h;
DOI:10.1016/S0040-4039(00)92786-2

Reference yield:

: 76504-35-3
tert-Butyl-[(1S,2R,3R)-2-(3-methoxy-2-methoxymethoxy-6-methylsulfanylmethoxymethyl-phenyl)-3-(2-methyl-propane-2-sulfonyl)-cyclohexyloxy]-dimethyl-silane

: (2R,3R)-2-(3-Methoxy-2-methoxymethoxy-6-methylsulfanylmethoxymethyl-phenyl)-3-(2-methyl-propane-2-sulfonyl)-cyclohexanone

Guidance literature:: Multi-step reaction with 2 steps

1: 989 percent / TBAF / tetrahydrofuran / 24 h / 25 °C

2: DMSO, TFAA / CH₂Cl₂

With tetrabutyl ammonium fluoride; dimethyl sulfoxide; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(00)92786-2