Technology Process of 6,6-ethylenedioxy-2α,3α-isopropylidenedioxy-22ξ-acetoxy-23ξ-phenylsulfonyl-24S-methyl-5α-cholestane
There total 11 articles about 6,6-ethylenedioxy-2α,3α-isopropylidenedioxy-22ξ-acetoxy-23ξ-phenylsulfonyl-24S-methyl-5α-cholestane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 97.8 percent / OsO4, N-methylmorpholine N-oxide / acetone; H2O
2: 100 percent / p-toluenesulfonic acid
3: p-toluenesulfonic acid
4: 1.) O3, 2.) Me2S, NaHCO3
With
osmium(VIII) oxide; dimethylsulfide; sodium hydrogencarbonate; toluene-4-sulfonic acid; ozone; 4-methylmorpholine N-oxide;
In
water; acetone;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 100 percent / p-toluenesulfonic acid
2: p-toluenesulfonic acid
3: 1.) O3, 2.) Me2S, NaHCO3
With
dimethylsulfide; sodium hydrogencarbonate; toluene-4-sulfonic acid; ozone;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 66 percent / p-TsOH / tetrahydrothiophene 1,1-dioxide / 1.17 h / 160 °C
2: 63 percent / OsO4,NMO / 2-methyl-propan-2-ol; acetone; H2O / 10 h
3: p-TsOH / CH2Cl2 / 1 h / Ambient temperature
4: p-TsOH / 3 h / Heating
5: 1.)O3, NaHCO3, 2.)Me2S / 1.)CH2Cl2, MeOH, -60 - -50 deg C, 3 h, 2.)R. T.
6: 1.)n-BuLi
With
osmium(VIII) oxide; n-butyllithium; dimethylsulfide; sodium hydrogencarbonate; toluene-4-sulfonic acid; ozone; 4-methylmorpholine N-oxide;
In
sulfolane; dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.1016/0040-4020(82)85157-0
