1,2-Benzisoxazol-3-ylacetyl chloride

Base Information

• Chemical Name: 1,2-Benzisoxazol-3-ylacetyl chloride
• CAS No.: 84637-43-4
• Molecular Formula: C₉H₆ClNO₂
• Molecular Weight: 195.605
• Mol file: 84637-43-4.mol

Synonyms:

Chemical Property of 1,2-Benzisoxazol-3-ylacetyl chloride

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

1,2-Benzisoxazol-3-ylacetyl chloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-Benzisoxazol-3-ylacetyl chloride

There total 2 articles about 1,2-Benzisoxazol-3-ylacetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(benzo[d]isoxazol-3-yl)acetic acid (4865-84-3) → 2-(1,2-benzisoxazol-3-yl)acetyl chloride (84637-43-4)

Guidance literature:

With phosphorus(V) chloride; at 30 - 40 ℃; for 1h;

Reference yield:

4-hydroxy[1]benzopyran-2-one (1076-38-6,92395-12-5) → 2-(1,2-benzisoxazol-3-yl)acetyl chloride (84637-43-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxyamino hydrochloride; sodium hydroxide / ethanol / 16 h / 81 °C

2: thionyl chloride / dichloromethane / 3 h / 0 - 40 °C

With thionyl chloride; hydroxyamino hydrochloride; sodium hydroxide; In ethanol; dichloromethane;

DOI:10.1021/acschemneuro.1c00846

Reference yield:

2-(1,2-benzisoxazol-3-yl)acetyl chloride (84637-43-4) → (E)-2-Benzo[d]isoxazol-3-yl-3-hydroxy-5-(2-hydroxy-phenyl)-5-oxo-pent-2-enoic acid methyl ester (84637-57-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 5 percent / NaH / dimethylformamide

2: 10 percent / NaOH / H₂O; dioxane / 100 °C

4: H₂ / 5percent Pd-C / dioxane; ethanol

5: acidic hydrolysis

With sodium hydroxide; hydrogen; sodium hydride; palladium on activated charcoal; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

2-(benzo[d]isoxazol-3-yl)acetic acid

4-hydroxy[1]benzopyran-2-one

Downstream raw materials:

(E)-2-Benzo[d]isoxazol-3-yl-3-hydroxy-5-(2-hydroxy-phenyl)-5-oxo-pent-2-enoic acid methyl ester

(E)-2-Benzo[d]isoxazol-3-yl-3,5-dihydroxy-5-(2-hydroxy-phenyl)-pent-2-enoic acid methyl ester

(2E,4E)-5-Amino-2-benzo[d]isoxazol-3-yl-3-hydroxy-5-(2-hydroxy-phenyl)-penta-2,4-dienoic acid methyl ester

(2E,4Z)-5-Amino-2-benzo[d]isoxazol-3-yl-3-hydroxy-5-(2-hydroxy-phenyl)-penta-2,4-dienoic acid methyl ester