(S)-2-[2-((S)-2-{(S)-2-[2-(2-Hydroxy-phenyl)-acetylamino]-3-phenyl-propionylamino}-3-phenyl-propionylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide

Base Information

• Chemical Name: (S)-2-[2-((S)-2-{(S)-2-[2-(2-Hydroxy-phenyl)-acetylamino]-3-phenyl-propionylamino}-3-phenyl-propionylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide
• CAS No.: 119372-38-2
• Molecular Formula: C₃₉H₅₀N₆O₇S
• Molecular Weight: 746.928

Synonyms:

Chemical Property of (S)-2-[2-((S)-2-{(S)-2-[2-(2-Hydroxy-phenyl)-acetylamino]-3-phenyl-propionylamino}-3-phenyl-propionylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[2-((S)-2-{(S)-2-[2-(2-Hydroxy-phenyl)-acetylamino]-3-phenyl-propionylamino}-3-phenyl-propionylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide

There total 9 articles about (S)-2-[2-((S)-2-{(S)-2-[2-(2-Hydroxy-phenyl)-acetylamino]-3-phenyl-propionylamino}-3-phenyl-propionylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

H-Phe-Phe-Gly-Leu-Met-NH2 (51165-05-0,78081-73-9) + (2-Hydroxy-phenyl)-acetic acid 2,4,5-trichloro-phenyl ester → (S)-2-[2-((S)-2-{(S)-2-[2-(2-Hydroxy-phenyl)-acetylamino]-3-phenyl-propionylamino}-3-phenyl-propionylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide (119372-38-2)

Guidance literature:

DOI:10.1016/0223-5234(88)90006-2

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → (S)-2-[2-((S)-2-{(S)-2-[2-(2-Hydroxy-phenyl)-acetylamino]-3-phenyl-propionylamino}-3-phenyl-propionylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide (119372-38-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 70 percent / NMM, IBCF / dimethylformamide / -15 °C

2: 85 percent / 1N NaOH / dioxane; methanol / 0 deg C, 5 h, RT

3: 54.6 percent / IBCF, NMMole / dimethylformamide / -20 °C

4: TFA, anisole / CH₂Cl₂ / 1 h / 0 °C

5: 83 percent

With 4-methyl-morpholine; sodium hydroxide; methoxybenzene; trifluoroacetic acid; isobutyl chloroformate; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(88)90006-2

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → (S)-2-[2-((S)-2-{(S)-2-[2-(2-Hydroxy-phenyl)-acetylamino]-3-phenyl-propionylamino}-3-phenyl-propionylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide (119372-38-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 93.6 percent / NMM, IBCF / dimethylformamide / -20 °C

2: TFA, anisole / CH₂Cl₂ / 1 h / 0 °C

3: 54.6 percent / IBCF, NMMole / dimethylformamide / -20 °C

4: TFA, anisole / CH₂Cl₂ / 1 h / 0 °C

5: 83 percent

With 4-methyl-morpholine; methoxybenzene; trifluoroacetic acid; isobutyl chloroformate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(88)90006-2

upstream raw materials:

H-Phe-Phe-Gly-Leu-Met-NH₂

N-tert-butoxycarbonyl-L-leucine

N-tert-butoxycarbonyl-L-leucyl-L-methioninamide

N-tert-butoxycarbonyl-L-phenylalanine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 119372-38-2 (S)-2-[2-((S)-2-{(S)-2-[2-(2-Hydroxy-phenyl)-acetylamino]-3-phenyl-propionylamino}-3-phenyl-propionylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide

Send

Send

Metric Ton KG G Pound L ML

Send

Send