(+)-cis-2,3-(Methylenedioxy)-9,10-dimethoxy-13-(hydroxymethyl)tetrahydroprotoberberine

Base Information

• Chemical Name: (+)-cis-2,3-(Methylenedioxy)-9,10-dimethoxy-13-(hydroxymethyl)tetrahydroprotoberberine
• CAS No.: 79082-06-7
• Molecular Formula: C₂₁H₂₃NO₅
• Molecular Weight: 369.417
• Mol file: 79082-06-7.mol

Synonyms:

Chemical Property of (+)-cis-2,3-(Methylenedioxy)-9,10-dimethoxy-13-(hydroxymethyl)tetrahydroprotoberberine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-cis-2,3-(Methylenedioxy)-9,10-dimethoxy-13-(hydroxymethyl)tetrahydroprotoberberine

There total 1 articles about (+)-cis-2,3-(Methylenedioxy)-9,10-dimethoxy-13-(hydroxymethyl)tetrahydroprotoberberine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methanesulfonic acid (13S,13aR)-9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-13-ylmethyl ester (78982-17-9) → (+)-cis-2,3-(Methylenedioxy)-9,10-dimethoxy-13-(hydroxymethyl)tetrahydroprotoberberine (79082-06-7) + thalictricavine (29550-24-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; for 2h; Yield given. Yields of byproduct given; Heating;

DOI:10.1021/jo00336a024

Reference yield:

(+)-cis-2,3-(Methylenedioxy)-9,10-dimethoxy-13-(hydroxymethyl)tetrahydroprotoberberine (79082-06-7) → thalictricavine (29550-24-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 1 h / 0 °C

2: LiAlH₄ / tetrahydrofuran; diethyl ether / 2 h / Heating

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jo00336a024

upstream raw materials:

Methanesulfonic acid (13S,13aR)-9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-13-ylmethyl ester

Downstream raw materials:

thalictricavine