(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (7S,8S)-8-hydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-7-yl ester

Base Information

• Chemical Name: (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (7S,8S)-8-hydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-7-yl ester
• CAS No.: 63227-55-4
• Molecular Formula: C₃₀H₂₃F₃O₄
• Molecular Weight: 504.505
• Mol file: 63227-55-4.mol

Synonyms:

Chemical Property of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (7S,8S)-8-hydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-7-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (7S,8S)-8-hydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-7-yl ester

There total 4 articles about (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (7S,8S)-8-hydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9,10-dihydro benzopyrene (17573-15-8) → (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (7S,8S)-8-hydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-7-yl ester (63227-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1: I₂

2: 1.) NaOMe

With iodine; sodium methylate;

DOI:10.1016/S0040-4039(00)76952-8

Reference yield:

7,8-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (36504-67-3,82079-65-0) + (S)-Mosher acid (17257-71-5,20445-31-2,56135-03-6,81655-41-6) → (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (7S,8S)-8-hydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-7-yl ester (63227-55-4) + (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (7R,8R)-8-hydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-7-yl ester (63268-36-0)

Guidance literature:

With aluminum oxide; In tetrahydrofuran; for 72h; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1016/S0040-4039(00)76952-8

Reference yield:

(S)-Mosher acid (17257-71-5,20445-31-2,56135-03-6,81655-41-6) + (+/-)-7,8,9,10-Tetrahydrobenzopyrene-trans-7,8-diol dibenzoate (57405-00-2,62896-79-1,63268-35-9,64912-52-3) → (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (7S,8S)-8-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-7,8,9,10-tetrahydro-benzo[def]chrysen-7-yl ester + (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (7S,8S)-7-hydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-8-yl ester + (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (7S,8S)-8-hydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-7-yl ester (63227-55-4) + (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (7R,8R)-8-hydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-7-yl ester (63268-36-0)

Guidance literature:

With sodium methylate; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given;

DOI:10.1016/S0040-4039(00)76952-8

upstream raw materials:

7,8-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene

(S)-Mosher acid

(+/-)-7,8,9,10-Tetrahydrobenzopyrene-trans-7,8-diol dibenzoate

9,10-dihydro benzopyrene

Downstream raw materials:

trans-(7S,8S)-7,8-dibenzoyloxy-7,8,9,10-tetrahydrobenzopyrene

(+/-)-trans-7,8-Dihydrobenzo[a]pyrene-7,8-diol

(7R,8S)-dihydroxy-(9S,10R)-epoxy-7,8,9,10-tetrahydrodibenzo[a]pyrene

C₃₄H₂₂O₄