Technology Process of Cyclopenta[b]pyrrole,
octahydro-6a-methyl-6-methylene-1-(phenylmethyl)-, cis-
There total 8 articles about Cyclopenta[b]pyrrole,
octahydro-6a-methyl-6-methylene-1-(phenylmethyl)-, cis- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl-ammonium chloride; sodium carbonate; tris-(o-tolyl)phosphine;
palladium diacetate;
In
N,N-dimethyl-formamide;
at 65 ℃;
for 48h;
DOI:10.1021/jo00035a006
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 90 percent / pyridinium chlorochromate, neutral alumina / CH2Cl2 / 12 h
2: 58 percent / NaH / tetrahydrofuran; hexane / 1.) 0 deg C, 35 min, then r.t., 25 min, 2.) 25 deg C, overnight
3: 91 percent / 1M DIBAL-H / toluene; hexane / 2 h / -78 °C
4: 82 percent / Hg(OAc)2 / 10 h / Heating
5: 87 percent / various solvent(s) / 17 h / Heating
6: 50 percent / NaBH3CN, 4 Angstroem moleculer sieves / methanol / 8 h / 25 °C
7: 10 percent / triethylamine, tri-o-tolylphosphine / Pd(OAc)2 / acetonitrile / 6 h / 75 °C
With
aluminum oxide; 4 A molecular sieve; mercury(II) diacetate; sodium hydride; diisobutylaluminium hydride; sodium cyanoborohydride; triethylamine; tris-(o-tolyl)phosphine; pyridinium chlorochromate;
palladium diacetate;
In
tetrahydrofuran; methanol; hexane; dichloromethane; toluene; acetonitrile;
DOI:10.1021/jo00072a030
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 58 percent / NaH / tetrahydrofuran; hexane / 1.) 0 deg C, 35 min, then r.t., 25 min, 2.) 25 deg C, overnight
2: 91 percent / 1M DIBAL-H / toluene; hexane / 2 h / -78 °C
3: 82 percent / Hg(OAc)2 / 10 h / Heating
4: 87 percent / various solvent(s) / 17 h / Heating
5: 50 percent / NaBH3CN, 4 Angstroem moleculer sieves / methanol / 8 h / 25 °C
6: 10 percent / triethylamine, tri-o-tolylphosphine / Pd(OAc)2 / acetonitrile / 6 h / 75 °C
With
4 A molecular sieve; mercury(II) diacetate; sodium hydride; diisobutylaluminium hydride; sodium cyanoborohydride; triethylamine; tris-(o-tolyl)phosphine;
palladium diacetate;
In
tetrahydrofuran; methanol; hexane; toluene; acetonitrile;
DOI:10.1021/jo00072a030
