C₂₆H₂₇ClN₂O₄

Base Information

• Chemical Name: C₂₆H₂₇ClN₂O₄
• CAS No.: 1256250-77-7
• Molecular Formula: C₂₆H₂₇ClN₂O₄
• Molecular Weight: 466.964
• Mol file: 1256250-77-7.mol

Synonyms:

Chemical Property of C₂₆H₂₇ClN₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₇ClN₂O₄

There total 5 articles about C₂₆H₂₇ClN₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H19Cl2NO3 (1256254-43-9) → C26H27ClN2O4 (1256250-77-7)

Guidance literature:

Multi-step reaction with 4 steps

1: palladium diacetate; 1,3-bis(dicyclohexylphosphino)propane bis(tetrafluoroborate) salt; potassium carbonate / N,N-dimethyl-formamide

2: potassium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl-formamide; water

3: lithium hydroxide; water / tetrahydrofuran

4: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; 1,3-bis(dicyclohexylphosphino)propane bis(tetrafluoroborate) salt; water; palladium diacetate; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;

DOI:10.1021/acsmedchemlett.6b00194

Reference yield:

C16H22ClNO5 → C26H27ClN2O4 (1256250-77-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl-formamide; water

2: lithium hydroxide; water / tetrahydrofuran

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; water; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; 1: |Suzuki Coupling;

DOI:10.1021/acsmedchemlett.6b00194

Reference yield:

C22H26ClNO5 → C26H27ClN2O4 (1256250-77-7)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hydroxide; water / tetrahydrofuran

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/acsmedchemlett.6b00194

upstream raw materials:

C₁₄H₁₉Cl₂NO₃

aniline