C₂₉H₂₅F₇INO₃

Base Information

• Chemical Name: C₂₉H₂₅F₇INO₃
• CAS No.: 1353643-28-3
• Molecular Formula: C₂₉H₂₅F₇INO₃
• Molecular Weight: 695.416
• Mol file: 1353643-28-3.mol

Synonyms:

Chemical Property of C₂₉H₂₅F₇INO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₉H₂₅F₇INO₃

There total 5 articles about C₂₉H₂₅F₇INO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

C29H27F7N2O3 (875550-81-5) → C29H25F7INO3 (1353643-28-3)

Guidance literature:

With n-Amyl nitrite; iodine; In chloroform; Reflux;

DOI:10.1016/j.bmcl.2011.11.039

Reference yield:

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one (875444-08-9) → C29H25F7INO3 (1353643-28-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0 °C

1.2: 0 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; water; toluene / Reflux

3.1: palladium on activated charcoal; hydrogen / methanol / 2068.65 Torr

4.1: n-Amyl nitrite; iodine / chloroform / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-Amyl nitrite; palladium on activated charcoal; hydrogen; iodine; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; ethanol; chloroform; water; toluene; 2.1: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.11.039

Reference yield:

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-(2-bromo-5-nitrobenzyl)-4-methyl-1,3-oxazolidin-2-one (875550-79-1) → C29H25F7INO3 (1353643-28-3)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; water; toluene / Reflux

2: palladium on activated charcoal; hydrogen / methanol / 2068.65 Torr

3: n-Amyl nitrite; iodine / chloroform / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-Amyl nitrite; palladium on activated charcoal; hydrogen; iodine; potassium carbonate; In methanol; ethanol; chloroform; water; toluene; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.11.039

upstream raw materials:

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-(2-bromo-5-nitrobenzyl)-4-methyl-1,3-oxazolidin-2-one

C₂₉H₂₅F₇N₂O₅

C₂₉H₂₇F₇N₂O₃

Downstream raw materials:

C₃₄H₃₂F₇NO₃

C₃₀H₂₈F₇NO₃

C₃₂H₃₂F₇NO₃

C₃₀H₂₅F₇N₂O₃