N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[4-(2-furoyl)piperazin-1-yl]acetamide

Base Information

Chemical Name:N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[4-(2-furoyl)piperazin-1-yl]acetamide
CAS No.:899713-86-1
Molecular Formula:C₁₈H₁₇ClF₃N₃O₃
Molecular Weight:415.799
Hs Code.:
European Community (EC) Number:809-791-4
Pharos Ligand ID:J53ZAFSPGKWG
ChEMBL ID:CHEMBL600764
Mol file:899713-86-1.mol

Synonyms:ML348;899713-86-1;ML 348;GNF-Pf-1127;N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[4-(2-furoyl)piperazin-1-yl]acetamide;N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide;ML-348(ML348);SMR000033454;N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[4-(furan-2-carbonyl)piperazin-1-yl]acetamide;N-(2-chloro-5-(trifluoromethyl)phenyl)-2-(4-(furan-2-carbonyl)piperazin-1-yl)acetamide;SR-01000595170;n-(2-chloro-5-(trifluoromethyl)phenyl)-4-(2-furanylcarbonyl)-1-piperazineacetamide;MLS000047443;MLS004819989;CHEMBL600764;BDBM207991;HMS2296O04;BCP18861;EX-A1091;ZKB71386;MFCD05123530;ML-348;s6564;STL419865;AKOS002133531;CS-5993;AC-35406;AS-16715;HY-100736;A16338;A903369;SR-01000595170-1;SR-01000595170-3;SR-01000595170-4;SR-01000595170-5;N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[4-(furan-2-ylcarbonyl)piperazin-1-yl]acetamide;CID 3238952;SID 160654487

Suppliers and Price of N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[4-(2-furoyl)piperazin-1-yl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
ML 348
10mg
$ 460.00

TRC
ML348
25mg
$ 400.00

TRC
ML348
10mg
$ 180.00

Tocris
ML348 ≥99%(HPLC)
10
$ 208.00

Tocris
ML348 ≥99%(HPLC)
50
$ 870.00

DC Chemicals
ML-348(ML348) >98%
100 mg
$ 500.00

DC Chemicals
ML-348(ML348) >98%
250 mg
$ 850.00

ChemScene
ML348 99.88%
10mg
$ 120.00

ChemScene
ML348 99.88%
5mg
$ 72.00

ChemScene
ML348 99.88%
100mg
$ 804.00

Total 16 raw suppliers

Chemical Property of N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[4-(2-furoyl)piperazin-1-yl]acetamide

Chemical Property:

Boiling Point:546.2±50.0 °C(Predicted)
PKA:13.13±0.70(Predicted)
Density:1.422±0.06 g/cm3(Predicted)
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:415.0910536
Heavy Atom Count:28
Complexity:570

Purity/Quality:

99%, ^*data from raw suppliers

ML 348 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCN1CC(=O)NC2=C(C=CC(=C2)C(F)(F)F)Cl)C(=O)C3=CC=CO3
Uses ML348 is a reversible LYPLA1 inhibitor. It is 14-fold selective for LYPLA1 over LYPLA2 and demonstrates little activity against a panel of more than 20 other serine hydrolases.

Technology Process of N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[4-(2-furoyl)piperazin-1-yl]acetamide

There total 1 articles about N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[4-(2-furoyl)piperazin-1-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%