Technology Process of 5-(adamantan-1-yl-methoxy)pentyl 3,4,6-tri-O-benzyl-2,5-dideoxy2,5-(pent-4-enimido)-L-gulohexonamide
There total 12 articles about 5-(adamantan-1-yl-methoxy)pentyl 3,4,6-tri-O-benzyl-2,5-dideoxy2,5-(pent-4-enimido)-L-gulohexonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
-
-
16838-89-4,17073-88-0,60933-68-8,60933-69-9,73068-66-3,89361-52-4,89615-42-9,89615-45-2,96192-07-3
2,3,5-tri-O-benzyl-D-xylofuranose
- Guidance literature:
-
Multi-step reaction with 8 steps
1: sodium tetrahydroborate / methanol / 3 h / 20 °C / Inert atmosphere
2: pyridine / 20 h / 40 °C / Inert atmosphere
3: triethylamine / dichloromethane / 20 h
4: sodium azide; 15-crown-5 / N,N-dimethyl-formamide / 48 h / 90 °C / Inert atmosphere
5: methanol; boron trifluoride diethyl etherate / toluene / 3 h / Inert atmosphere
6: Dess-Martin periodane / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere
7: trimethylphosphane / methanol; toluene / 3 h / 0 °C / Inert atmosphere
8: methanol / 0 - 5 °C / Inert atmosphere
With
pyridine; methanol; sodium tetrahydroborate; sodium azide; 15-crown-5; boron trifluoride diethyl etherate; Dess-Martin periodane; triethylamine; trimethylphosphane;
In
methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
8: |Ugi Condensation;
DOI:10.1002/ejoc.201200923
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium azide / dimethyl sulfoxide / 20 h / 20 °C / Inert atmosphere
2: water; trimethylphosphane / tetrahydrofuran / 3 h / 0 °C
3: dichloromethane / 20 h / 0 - 20 °C
4: triethylamine; trichlorophosphate / dichloromethane / 1 h / -30 °C / Inert atmosphere
5: methanol / 0 - 5 °C / Inert atmosphere
With
methanol; sodium azide; water; triethylamine; trichlorophosphate; trimethylphosphane;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
5: |Ugi Condensation;
DOI:10.1002/ejoc.201200923
- Guidance literature:
-
Multi-step reaction with 3 steps
1: dichloromethane / 20 h / 0 - 20 °C
2: triethylamine; trichlorophosphate / dichloromethane / 1 h / -30 °C / Inert atmosphere
3: methanol / 0 - 5 °C / Inert atmosphere
With
methanol; triethylamine; trichlorophosphate;
In
dichloromethane;
3: |Ugi Condensation;
DOI:10.1002/ejoc.201200923
