C₂₃H₂₇NO₄

Base Information

• Chemical Name: C₂₃H₂₇NO₄
• CAS No.: 1423014-74-7
• Molecular Formula: C₂₃H₂₇NO₄
• Molecular Weight: 381.472
• Mol file: 1423014-74-7.mol

Synonyms:

Chemical Property of C₂₃H₂₇NO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₇NO₄

There total 6 articles about C₂₃H₂₇NO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H15NO2 + 2-(3,4-dimethoxyphenyl)ethyl alcohol (7417-21-2) → C23H27NO4 (1423014-74-7)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/jm301774u

Reference yield:

3-phenyl ethyl isonicotinate (1261743-67-2) → C23H27NO4 (1423014-74-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: acetone / 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate / ethanol / 1 h / 20 °C / Inert atmosphere

3.1: potassium hydroxide / ethanol; water / 20 °C / Inert atmosphere

3.2: pH 6 / Inert atmosphere

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In ethanol; dichloromethane; water; acetone; 4.1: |Steglich Esterification;

DOI:10.1021/jm301774u

Reference yield:

3-bromoisonicotinic acid (13959-02-9) → C23H27NO4 (1423014-74-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sulfuric acid / Reflux; Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran / 4 h / 65 °C / Inert atmosphere

3.1: acetone / 20 °C / Inert atmosphere

4.1: sodium tetrahydroborate / ethanol / 1 h / 20 °C / Inert atmosphere

5.1: potassium hydroxide / ethanol; water / 20 °C / Inert atmosphere

5.2: pH 6 / Inert atmosphere

6.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; acetone; 2.1: |Suzuki Coupling / 6.1: |Steglich Esterification;

DOI:10.1021/jm301774u

upstream raw materials:

2-(3,4-dimethoxyphenyl)ethyl alcohol

3-phenyl ethyl isonicotinate

ethyl 3-bromopyridine-4-carboxylate

3-bromoisonicotinic acid