allyl-[(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propyl]-amine

Base Information

Chemical Name:allyl-[(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propyl]-amine
CAS No.:1435050-80-8
Molecular Formula:C₁₈H₁₉F₂NO
Molecular Weight:303.352
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of allyl-[(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propyl]-amine

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Technology Process of allyl-[(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propyl]-amine

There total 10 articles about allyl-[(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1434720-26-9
(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propylamine

: 106-95-6
allyl bromide

: 1435050-80-8
allyl-[(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propyl]-amine

Guidance literature:

Reference yield:

: 98-80-6
phenylboronic acid

: 1435050-80-8
allyl-[(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propyl]-amine

Guidance literature:: Multi-step reaction with 5 steps

1: copper diacetate; pyridine; pyridine N-oxide / dichloromethane / 48 h / 20 °C / Molecular sieve

2: titanium(IV) tetraethanolate / dichloromethane / Inert atmosphere

3: tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

4: hydrogenchloride / methanol; 1,4-dioxane / 1 h

With pyridine; pyridine N-oxide; hydrogenchloride; titanium(IV) tetraethanolate; copper diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 261763-46-6
3-methyl-2,6-difluorophenol

: 1435050-80-8
allyl-[(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propyl]-amine

Guidance literature:: Multi-step reaction with 7 steps

1: cesium fluoride / acetonitrile / Inert atmosphere

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 - 90 °C / Inert atmosphere

3: sodium hydrogencarbonate; dimethyl sulfoxide / 80 °C / Inert atmosphere

4: titanium(IV) tetraethanolate / dichloromethane / Inert atmosphere

5: tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

6: hydrogenchloride / methanol; 1,4-dioxane / 1 h

With hydrogenchloride; titanium(IV) tetraethanolate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydrogencarbonate; dimethyl sulfoxide; cesium fluoride; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; acetonitrile;