Technology Process of C22H21F3N2O5S
There total 6 articles about C22H21F3N2O5S which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-(4-((S)-(benzyloxy)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)quinolin-6-yl)-4-methylbenzenesulfonamide;
In
dichloromethane;
at 20 ℃;
for 16h;
Overall yield = 97 %; stereoselective reaction;
DOI:10.1021/acs.joc.5b01660
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: Reflux
2.1: bromine / 1,2-dichloro-ethane
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h
3.2: 0.5 h
4.1: C43H36F6N4OS / dichloromethane / 20 °C
With
C43H36F6N4OS; bromine; sodium hydride;
In
tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; mineral oil;
DOI:10.1055/s-0032-1317081
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: bromine / 1,2-dichloro-ethane
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h
2.2: 0.5 h
3.1: C43H36F6N4OS / dichloromethane / 20 °C
With
C43H36F6N4OS; bromine; sodium hydride;
In
tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; mineral oil;
DOI:10.1055/s-0032-1317081