C₄₈H₅₆N₁₀O₆S₂

Base Information

Chemical Name:C₄₈H₅₆N₁₀O₆S₂
CAS No.:1332639-62-9
Molecular Formula:C₄₈H₅₆N₁₀O₆S₂
Molecular Weight:933.168
Hs Code.:

C<sub>48</sub>H<sub>56</sub>N<sub>10</sub>O<sub>6</sub>S<sub>2</sub>

Synonyms:

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Chemical Property of C₄₈H₅₆N₁₀O₆S₂

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Technology Process of C₄₈H₅₆N₁₀O₆S₂

There total 29 articles about C₄₈H₅₆N₁₀O₆S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 187039-57-2,335280-19-8
(2S,3S)-1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid

: 1332639-62-9
C₄₈H₅₆N₁₀O₆S₂

Guidance literature:: Multi-step reaction with 22 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 90 °C

2.1: 1H-imidazole / dichloromethane / 6 h / 0 - 20 °C

3.1: lithium borohydride / tetrahydrofuran / 3 h / 0 - 20 °C

4.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 20 °C

5.1: triethylamine / 12 h

6.1: thionyl chloride / dichloromethane / 1 h / -78 °C

6.2: 1 h / -78 °C

7.1: / acetonitrile / 16 h / 20 °C

8.1: hydrogen / ethanol / 1.5 h / 2585.81 Torr

9.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 - 45 °C

11.1: dmap / dichloromethane / 3 h / 0 °C

12.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

13.1: sodium periodate / ruthenium(III) trichloride hydrate / 1-methyl-pyrrolidin-2-one; tetrachloromethane; acetonitrile; water / 3.83 h

14.1: triethylamine / diethyl ether; tetrahydrofuran / 20 °C

14.2: 1 h / -30 °C

14.3: 19 h / -30 - 20 °C

15.1: hydrogen bromide / 1,4-dioxane / 0.5 h / 0 - 20 °C

16.1: ethanol / 19 h / Reflux

17.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 3 h / Reflux

18.1: trifluoroacetic acid / dichloromethane / 3 h / 0 °C

19.1: HATU / 1-methyl-pyrrolidin-2-one

20.1: Grubbs catalyst first generation

21.1: triethylamine

22.1: trifluoroacetic acid / dichloromethane

With 1H-imidazole; dmap; sodium periodate; lithium borohydride; thionyl chloride; tetrabutyl ammonium fluoride; hydrogen bromide; hydrogen; sulfur trioxide pyridine complex; sodium hydride; potassium carbonate; triethylamine; HATU; trifluoroacetic acid; Grubbs catalyst first generation; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ruthenium(III) trichloride hydrate; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 184046-78-4
(2S,3S)-1-tert-butyl-2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate

: 1332639-62-9
C₄₈H₅₆N₁₀O₆S₂

Guidance literature:: Multi-step reaction with 21 steps

1.1: 1H-imidazole / dichloromethane / 6 h / 0 - 20 °C

2.1: lithium borohydride / tetrahydrofuran / 3 h / 0 - 20 °C

3.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 20 °C

4.1: triethylamine / 12 h

5.1: thionyl chloride / dichloromethane / 1 h / -78 °C

5.2: 1 h / -78 °C

6.1: / acetonitrile / 16 h / 20 °C

7.1: hydrogen / ethanol / 1.5 h / 2585.81 Torr

8.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 - 45 °C

10.1: dmap / dichloromethane / 3 h / 0 °C

11.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

12.1: sodium periodate / ruthenium(III) trichloride hydrate / 1-methyl-pyrrolidin-2-one; tetrachloromethane; acetonitrile; water / 3.83 h

13.1: triethylamine / diethyl ether; tetrahydrofuran / 20 °C

13.2: 1 h / -30 °C

13.3: 19 h / -30 - 20 °C

14.1: hydrogen bromide / 1,4-dioxane / 0.5 h / 0 - 20 °C

15.1: ethanol / 19 h / Reflux

16.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 3 h / Reflux

17.1: trifluoroacetic acid / dichloromethane / 3 h / 0 °C

18.1: HATU / 1-methyl-pyrrolidin-2-one

19.1: Grubbs catalyst first generation

20.1: triethylamine

21.1: trifluoroacetic acid / dichloromethane

With 1H-imidazole; dmap; sodium periodate; lithium borohydride; thionyl chloride; tetrabutyl ammonium fluoride; hydrogen bromide; hydrogen; sulfur trioxide pyridine complex; sodium hydride; potassium carbonate; triethylamine; HATU; trifluoroacetic acid; Grubbs catalyst first generation; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ruthenium(III) trichloride hydrate; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 156129-73-6
tert-butyl (2R,3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-(hydroxymethyl)pyrrolidine-1-carboxylate

: 1332639-62-9
C₄₈H₅₆N₁₀O₆S₂

Guidance literature:: Multi-step reaction with 19 steps

1.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 20 °C

2.1: triethylamine / 12 h

3.1: thionyl chloride / dichloromethane / 1 h / -78 °C

3.2: 1 h / -78 °C

4.1: / acetonitrile / 16 h / 20 °C

5.1: hydrogen / ethanol / 1.5 h / 2585.81 Torr

6.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 - 45 °C

8.1: dmap / dichloromethane / 3 h / 0 °C

9.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

10.1: sodium periodate / ruthenium(III) trichloride hydrate / 1-methyl-pyrrolidin-2-one; tetrachloromethane; acetonitrile; water / 3.83 h

11.1: triethylamine / diethyl ether; tetrahydrofuran / 20 °C

11.2: 1 h / -30 °C

11.3: 19 h / -30 - 20 °C

12.1: hydrogen bromide / 1,4-dioxane / 0.5 h / 0 - 20 °C

13.1: ethanol / 19 h / Reflux

14.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 3 h / Reflux

15.1: trifluoroacetic acid / dichloromethane / 3 h / 0 °C

16.1: HATU / 1-methyl-pyrrolidin-2-one

17.1: Grubbs catalyst first generation

18.1: triethylamine

19.1: trifluoroacetic acid / dichloromethane

With dmap; sodium periodate; thionyl chloride; tetrabutyl ammonium fluoride; hydrogen bromide; hydrogen; sulfur trioxide pyridine complex; sodium hydride; potassium carbonate; triethylamine; HATU; trifluoroacetic acid; Grubbs catalyst first generation; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ruthenium(III) trichloride hydrate; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;