Technology Process of (±)-2-(4-methoxyphenyl)-3,4-dihydro-2H-benzo[4,5]-thiazolo[3,2-a]pyrimidine
There total 5 articles about (±)-2-(4-methoxyphenyl)-3,4-dihydro-2H-benzo[4,5]-thiazolo[3,2-a]pyrimidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium carbonate / acetonitrile / 0 °C / Inert atmosphere
2.1: sodium iodide / acetonitrile / 8 h / 0 - 80 °C / Inert atmosphere
3.1: tetrahydrofuran / -15 °C / Inert atmosphere
3.2: 0.5 h / -15 °C / Inert atmosphere
4.1: trifluoroacetic acid; triethylsilane / 6 h / -15 °C / Inert atmosphere
With
triethylsilane; sodium carbonate; trifluoroacetic acid; sodium iodide;
In
tetrahydrofuran; acetonitrile;
3.1: |Grignard Reaction;
DOI:10.1021/jo400603n
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrahydrofuran / -15 °C / Inert atmosphere
1.2: 0.5 h / -15 °C / Inert atmosphere
2.1: trifluoroacetic acid; triethylsilane / 6 h / -15 °C / Inert atmosphere
With
triethylsilane; trifluoroacetic acid;
In
tetrahydrofuran;
1.1: |Grignard Reaction;
DOI:10.1021/jo400603n
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium carbonate / acetonitrile / 0 - 80 °C / Inert atmosphere
2.1: tetrahydrofuran / -15 °C / Inert atmosphere
2.2: 0.5 h / -15 °C / Inert atmosphere
3.1: trifluoroacetic acid; triethylsilane / 6 h / -15 °C / Inert atmosphere
With
triethylsilane; sodium carbonate; trifluoroacetic acid;
In
tetrahydrofuran; acetonitrile;
2.1: |Grignard Reaction;
DOI:10.1021/jo400603n
