(S)-2-{(S)-4-Benzyloxycarbonyl-2-[(S)-4-benzyloxycarbonyl-2-((S)-4-benzyloxycarbonyl-2-octanoylamino-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid dibenzyl ester

Base Information

• Chemical Name: (S)-2-{(S)-4-Benzyloxycarbonyl-2-[(S)-4-benzyloxycarbonyl-2-((S)-4-benzyloxycarbonyl-2-octanoylamino-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid dibenzyl ester
• CAS No.: 146552-87-6
• Molecular Formula: C₆₃H₇₄N₄O₁₄
• Molecular Weight: 1111.3
• Mol file: 146552-87-6.mol

Synonyms:

Chemical Property of (S)-2-{(S)-4-Benzyloxycarbonyl-2-[(S)-4-benzyloxycarbonyl-2-((S)-4-benzyloxycarbonyl-2-octanoylamino-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid dibenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-{(S)-4-Benzyloxycarbonyl-2-[(S)-4-benzyloxycarbonyl-2-((S)-4-benzyloxycarbonyl-2-octanoylamino-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid dibenzyl ester

There total 7 articles about (S)-2-{(S)-4-Benzyloxycarbonyl-2-[(S)-4-benzyloxycarbonyl-2-((S)-4-benzyloxycarbonyl-2-octanoylamino-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-Glu(OBzl)-OH (13574-13-5) → (S)-2-{(S)-4-Benzyloxycarbonyl-2-[(S)-4-benzyloxycarbonyl-2-((S)-4-benzyloxycarbonyl-2-octanoylamino-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid dibenzyl ester (146552-87-6)

Guidance literature:

Multi-step reaction with 5 steps

1: Et₃N, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide / CH₂Cl₂

2: HCl / ethyl acetate

3: Et₃N, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide / CH₂Cl₂

4: HCl / ethyl acetate

5: 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide / CH₂Cl₂

With hydrogenchloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; ethyl acetate;

DOI:10.1246/bcsj.66.2196

Reference yield:

H-Glu(OBzl)-Glu(OBzl)-OBzl (82082-83-5) → (S)-2-{(S)-4-Benzyloxycarbonyl-2-[(S)-4-benzyloxycarbonyl-2-((S)-4-benzyloxycarbonyl-2-octanoylamino-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid dibenzyl ester (146552-87-6)

Guidance literature:

Multi-step reaction with 5 steps

1: Et₃N, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide / CH₂Cl₂

2: HCl / ethyl acetate

3: Et₃N, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide / CH₂Cl₂

4: HCl / ethyl acetate

5: 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide / CH₂Cl₂

With hydrogenchloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; ethyl acetate;

DOI:10.1246/bcsj.66.2196

Reference yield:

N-tertbutyloxycarbonyl dipeptide of benzyl glutamate (89092-61-5) → (S)-2-{(S)-4-Benzyloxycarbonyl-2-[(S)-4-benzyloxycarbonyl-2-((S)-4-benzyloxycarbonyl-2-octanoylamino-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid dibenzyl ester (146552-87-6)

Guidance literature:

Multi-step reaction with 6 steps

1: HCl / ethyl acetate

2: Et₃N, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide / CH₂Cl₂

3: HCl / ethyl acetate

4: Et₃N, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide / CH₂Cl₂

5: HCl / ethyl acetate

6: 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide / CH₂Cl₂

With hydrogenchloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; ethyl acetate;

DOI:10.1246/bcsj.66.2196

upstream raw materials:

Octanoic acid

Glu(OBzl)4-OBzl

Boc-Glu(OBzl)-OH

H-Glu(OBzl)-Glu(OBzl)-OBzl