3-methoxy-2-hydroxy-α-methylstyrene

Base Information

• Chemical Name: 3-methoxy-2-hydroxy-α-methylstyrene
• CAS No.: 87307-81-1
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.204
• Mol file: 87307-81-1.mol

Synonyms:

Chemical Property of 3-methoxy-2-hydroxy-α-methylstyrene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methoxy-2-hydroxy-α-methylstyrene

There total 7 articles about 3-methoxy-2-hydroxy-α-methylstyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-hydroxy-3-methoxy-phenyl)-propan-2-ol (21022-76-4) → 3-methoxy-2-hydroxy-α-methylstyrene (87307-81-1)

Guidance literature:

at 195 - 200 ℃;

DOI:10.1021/ja01279a044

Reference yield:

2-benzyloxy-3-methoxybenzaldehyde (2011-06-5) → 3-methoxy-2-hydroxy-α-methylstyrene (87307-81-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / LiBr / diethyl ether / 1 h / 0 °C

2: 89 percent / pyridinium chlorochromate / CH₂Cl₂ / 5 h / 25 °C

3: 5.10 g / diethyl ether / 5 h / Heating

4: hydroquinone / 0.5 h / 180 - 200 °C

With hydroquinone; pyridinium chlorochromate; lithium bromide; In diethyl ether; dichloromethane;

DOI:10.1021/jo00172a032

Reference yield:

1-<3-methoxy-2-(phenylmethoxy)phenyl>ethanol (87307-78-6) → 3-methoxy-2-hydroxy-α-methylstyrene (87307-81-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / pyridinium chlorochromate / CH₂Cl₂ / 5 h / 25 °C

2: 5.10 g / diethyl ether / 5 h / Heating

3: hydroquinone / 0.5 h / 180 - 200 °C

With hydroquinone; pyridinium chlorochromate; In diethyl ether; dichloromethane;

DOI:10.1021/jo00172a032

upstream raw materials:

2-(2-hydroxy-3-methoxy-phenyl)-propan-2-ol

2-(2-(benzyloxy)-3-methoxyphenyl)propan-2-ol

2-benzyloxy-3-methoxybenzaldehyde

1-<3-methoxy-2-(phenylmethoxy)phenyl>ethanol

Downstream raw materials:

3-Isopropyl-veratrol

3-isopropyl-4,5-dimethoxy-aniline

1-isopropyl-2,3-dimethoxy-5-nitro-benzene

1-isopropyl-2,3-dimethoxy-4,5-dinitro-benzene

Refernces