Acetic acid (10R,13S,17S)-6-fluoro-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Base Information

• Chemical Name: Acetic acid (10R,13S,17S)-6-fluoro-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester
• CAS No.: 4069-09-4
• Molecular Formula: C₂₁H₂₉FO₃
• Molecular Weight: 348.458
• Mol file: 4069-09-4.mol

Synonyms:

Chemical Property of Acetic acid (10R,13S,17S)-6-fluoro-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (10R,13S,17S)-6-fluoro-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

There total 12 articles about Acetic acid (10R,13S,17S)-6-fluoro-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3,17-Diacetoxy-Δ3.5-androstadien (1778-93-4,3591-21-7,4223-51-2) → Acetic acid (10R,13S,17S)-6-fluoro-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester (855-55-0,2627-94-3,4068-89-7,4069-09-4,95343-39-8)

Guidance literature:

With N-fluoropyridinium triflate; In dichloromethane; for 10h; Heating;

DOI:10.1016/S0040-4039(00)84980-1

Reference yield: 36.0%

Acetic acid (10R,13S,17S)-10,13-dimethyl-3-trimethylsilanyloxy-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester (25495-29-8) → Acetic acid (10R,13S,17S)-6-fluoro-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester (855-55-0,2627-94-3,4068-89-7,4069-09-4,95343-39-8) + Acetic acid (10R,13S,17S)-4-fluoro-10,13-dimethyl-3-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester (147540-94-1)

Guidance literature:

With N-fluoro-4-methylpyridinium-2-sulfonate;

DOI:10.1016/S0022-1139(00)83715-X

Reference yield:

3,17-Diacetoxy-Δ3.5-androstadien (1778-93-4,3591-21-7,4223-51-2) → 6β-Fluor-testosteron-acetat (855-55-0,2627-94-3,4068-89-7,4069-09-4,95343-39-8) + 6α-Fluor-testosteronacetat (855-55-0,2627-94-3,4068-89-7,4069-09-4,95343-39-8)

Guidance literature:

With sodium hydrogencarbonate; N,N’-difluoro-2,2’-bipyridinium bis(tetrafluoroborate); In acetonitrile; at 70 ℃; for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo972338q

upstream raw materials:

3,17-Diacetoxy-Δ^3.5-androstadien

Acetic acid (10R,13S,17S)-10,13-dimethyl-3-trimethylsilanyloxy-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl ester