(S)-2-(2-{2-[(S)-2,5-Dioxo-3-(4,5,6,7-tetrabromo-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pyrrolidin-1-yl]-acetylamino}-acetylamino)-3-(4-hydroxy-phenyl)-propionic acid methyl ester

Base Information

Chemical Name:(S)-2-(2-{2-[(S)-2,5-Dioxo-3-(4,5,6,7-tetrabromo-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pyrrolidin-1-yl]-acetylamino}-acetylamino)-3-(4-hydroxy-phenyl)-propionic acid methyl ester
CAS No.:138202-52-5
Molecular Formula:C₂₆H₂₀Br₄N₄O₉
Molecular Weight:852.082
Hs Code.:

(S)-2-(2-{2-[(S)-2,5-Dioxo-3-(4,5,6,7-tetrabromo-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pyrrolidin-1-yl]-acetylamino}-acetylamino)-3-(4-hydroxy-phenyl)-propionic acid methyl ester

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Chemical Property of (S)-2-(2-{2-[(S)-2,5-Dioxo-3-(4,5,6,7-tetrabromo-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pyrrolidin-1-yl]-acetylamino}-acetylamino)-3-(4-hydroxy-phenyl)-propionic acid methyl ester

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Technology Process of (S)-2-(2-{2-[(S)-2,5-Dioxo-3-(4,5,6,7-tetrabromo-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pyrrolidin-1-yl]-acetylamino}-acetylamino)-3-(4-hydroxy-phenyl)-propionic acid methyl ester

There total 3 articles about (S)-2-(2-{2-[(S)-2,5-Dioxo-3-(4,5,6,7-tetrabromo-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pyrrolidin-1-yl]-acetylamino}-acetylamino)-3-(4-hydroxy-phenyl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 138202-17-2
N²-tetrabromophthaloyl-L-aspartic anhydride

: 138202-52-5
(S)-2-(2-{2-[(S)-2,5-Dioxo-3-(4,5,6,7-tetrabromo-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pyrrolidin-1-yl]-acetylamino}-acetylamino)-3-(4-hydroxy-phenyl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / acetic acid / 1.) 20 deg C, 30 min, 2.) 120 deg C

2: 1.) triethylamine, 2.) dicyclohexy;carbodiimine / 1.) dioxane, DMF, 20 deg C, 15 min, 2.) dioxane, DMF, from 0 deg C to RT, 53 h

With triethylamine; dicyclohexyl-carbodiimide; In acetic acid;

Reference yield:

: 98352-79-5
tetrabromophthaloyl-L-aspartic acid

: 138202-52-5
(S)-2-(2-{2-[(S)-2,5-Dioxo-3-(4,5,6,7-tetrabromo-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pyrrolidin-1-yl]-acetylamino}-acetylamino)-3-(4-hydroxy-phenyl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / acetic anhydride / benzene / 0.5 h / Heating

2: 92 percent / acetic acid / 1.) 20 deg C, 30 min, 2.) 120 deg C

3: 1.) triethylamine, 2.) dicyclohexy;carbodiimine / 1.) dioxane, DMF, 20 deg C, 15 min, 2.) dioxane, DMF, from 0 deg C to RT, 53 h

With acetic anhydride; triethylamine; dicyclohexyl-carbodiimide; In acetic acid; benzene;

Reference yield:

: 3417-91-2
L-tyrosine methyl ester HCl

: 138202-30-9
{2-[(S)-2,5-Dioxo-3-(4,5,6,7-tetrabromo-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pyrrolidin-1-yl]-acetylamino}-acetic acid

: 138202-52-5
(S)-2-(2-{2-[(S)-2,5-Dioxo-3-(4,5,6,7-tetrabromo-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pyrrolidin-1-yl]-acetylamino}-acetylamino)-3-(4-hydroxy-phenyl)-propionic acid methyl ester

Guidance literature:: With triethylamine; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) dioxane, DMF, 20 deg C, 15 min, 2.) dioxane, DMF, from 0 deg C to RT, 53 h;