(+/-) 1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl) 2,3-dihydroxymethyl butane

Base Information

• Chemical Name: (+/-) 1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl) 2,3-dihydroxymethyl butane
• CAS No.: 79288-75-8
• Molecular Formula: C₂₃H₃₂O₇
• Molecular Weight: 420.503
• Mol file: 79288-75-8.mol

Synonyms:

Chemical Property of (+/-) 1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl) 2,3-dihydroxymethyl butane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-) 1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl) 2,3-dihydroxymethyl butane

There total 6 articles about (+/-) 1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl) 2,3-dihydroxymethyl butane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(+/-) 1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl) butane 2,3-dicarboxylic acid dimethyl ester (139501-46-5) → (+/-) 1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl) 2,3-dihydroxymethyl butane (79288-75-8,139627-82-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Heating;

DOI:10.1016/S0040-4020(01)81005-X

Reference yield:

3,4,5-trimethoxy-benzaldehyde (86-81-7) → (+/-) 1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl) 2,3-dihydroxymethyl butane (79288-75-8,139627-82-0)

Guidance literature:

Multi-step reaction with 4 steps

1: Stobbe condensation

2: Raney Ni-Al alloy / aq. NaOH

3: methanol; diethyl ether

4: 77 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

With lithium aluminium tetrahydride; Raney Ni-Al alloy; In tetrahydrofuran; methanol; sodium hydroxide; diethyl ether;

DOI:10.1016/S0040-4020(01)81005-X

Reference yield:

veratrylidene (3,4,5-trimethoxy)benzylidene succinic acid → (+/-) 1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl) 2,3-dihydroxymethyl butane (79288-75-8,139627-82-0)

Guidance literature:

Multi-step reaction with 3 steps

1: Raney Ni-Al alloy / aq. NaOH

2: methanol; diethyl ether

3: 77 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

With lithium aluminium tetrahydride; Raney Ni-Al alloy; In tetrahydrofuran; methanol; sodium hydroxide; diethyl ether;

DOI:10.1016/S0040-4020(01)81005-X

upstream raw materials:

2-3,4-dimethoxybenzyl-3-3',4',5'-trimethoxybenzylbutyrolactone

(2R,3R)-2-4-hydroxy-3-methoxybenzyl-3-3',4',5'-trimethoxybenzylbutyrolactone

(+/-) 1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl) butane 2,3-dicarboxylic acid dimethyl ester

3,4,5-trimethoxy-benzaldehyde

Downstream raw materials:

(+/-) 1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl) 2,3-dimethoxymethyl butane

Refernces

• 1、 Nishibe,Okabe,Hisada. "Isolation of phenolic compounds and spectroscopic analysis of a new lignan from Trachelospermum asiaticum var. intermedium". . p. 2078 - 2082. Retrieved 2007/10/02.