ester methylic d'endocarboxy-2 bicyclo<2.2.1>heptanone-6

Base Information

• Chemical Name: ester methylic d'endocarboxy-2 bicyclo<2.2.1>heptanone-6
• CAS No.: 57969-25-2
• Molecular Formula: C₉H₁₂O₃
• Molecular Weight: 168.192
• Mol file: 57969-25-2.mol

Synonyms:

Chemical Property of ester methylic d'endocarboxy-2 bicyclo<2.2.1>heptanone-6

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ester methylic d'endocarboxy-2 bicyclo<2.2.1>heptanone-6

There total 1 articles about ester methylic d'endocarboxy-2 bicyclo<2.2.1>heptanone-6 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-norbornene-endo-2-carboxylic acid (934-30-5,1195-12-6,20507-53-3,58001-99-3,67999-50-2,67999-53-5,74645-32-2,108266-75-7,120-74-1) → C13H17N3O + endo-2-hydroxy-exo-6-(carbomethoxy)bicyclo<2.2.1>heptane (68024-14-6,68069-51-2,71358-92-4,71358-93-5,75364-29-3) + methyl 6-(N-(tert-butoxycarbonyl)-2-ethoxy-2-oxoacetamido)bicyclo[2.2.1]heptane-2-carboxylate + C57H74N8O13S + bicyclo<2.2.1>hept-5-ene-exo-2-carboxylic acid N-hydroxysuccinimide ester + ester methylic d'endocarboxy-2 bicyclo<2.2.1>heptanone-6 (57969-25-2,68069-50-1,70680-88-5,70680-89-6,108211-82-1)

Guidance literature:

Multi-step reaction with 3 steps

1: dicyclohexyl-carbodiimide / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 25 °C / Inert atmosphere

3: dmap / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/anie.201305645

Reference yield:

ester methylic d'endocarboxy-2 bicyclo<2.2.1>heptanone-6 (57969-25-2,68069-50-1,70680-88-5,70680-89-6,108211-82-1) → (1R,3R,6S,7R,9R)-4-Benzyl-4-aza-tricyclo[4.2.1.03,7]nonan-9-ol (78422-89-6,89826-14-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) HCl 2.) H₂ / PtO₂ / 1.) MeOH, 70h 2.) 1 atm

2: 72 h / 30 °C / catalyst: Beauveria sulfurescens

3: 57 mg / LiAlH₄ / tetrahydrofuran / Heating

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; platinum(IV) oxide; In tetrahydrofuran;

DOI:10.1016/S0040-4020(01)91182-2

Reference yield:

ester methylic d'endocarboxy-2 bicyclo<2.2.1>heptanone-6 (57969-25-2,68069-50-1,70680-88-5,70680-89-6,108211-82-1) → (1S,3S,6S,7S,9S)-4-Benzyl-9-hydroxy-4-aza-tricyclo[4.2.1.03,7]nonan-5-one (78422-84-1,89826-05-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) HCl 2.) H₂ / PtO₂ / 1.) MeOH, 70h 2.) 1 atm

2: 72 h / 30 °C / catalyst: Beauveria sulfurescens

With hydrogenchloride; hydrogen; platinum(IV) oxide;

DOI:10.1016/S0040-4020(01)91182-2

upstream raw materials:

5-norbornene-endo-2-carboxylic acid

Downstream raw materials:

N-benzyl aza-4 brendanone-5

(1R,3R,6S,7R,9R)-4-Benzyl-4-aza-tricyclo[4.2.1.0^3,7]nonan-9-ol

(1S,3S,6S,7S,9S)-4-Benzyl-9-hydroxy-4-aza-tricyclo[4.2.1.0^3,7]nonan-5-one