anti-9,10-Dihydroxy-7,8-epoxy-7,8,9,10-tetrahydrobenzo(f)quinoline

Base Information

Chemical Name:anti-9,10-Dihydroxy-7,8-epoxy-7,8,9,10-tetrahydrobenzo(f)quinoline
CAS No.:103620-40-2
Molecular Formula:C₁₃H₁₁NO₃
Molecular Weight:229.235
Hs Code.:
DSSTox Substance ID:DTXSID70908524

Synonyms:103620-40-2;DTXSID70908524;anti-9,10-Dihydroxy-7,8-epoxy-7,8,9,10-tetrahydrobenzo(f)quinoline;119478-48-7;Oxireno(3,4)benzo(1,2-f)quinoline-8,9-diol, 1a,8,9,9a-tetrahydro-, (1aalpha,8alpha,9beta,9aalpha)-;1a,8,9,9a-tetrahydro[1]benzoxireno[3,2-f]quinoline-8,9-diol

Suppliers and Price of anti-9,10-Dihydroxy-7,8-epoxy-7,8,9,10-tetrahydrobenzo(f)quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of anti-9,10-Dihydroxy-7,8-epoxy-7,8,9,10-tetrahydrobenzo(f)quinoline

Chemical Property:

Vapor Pressure:8.14E-11mmHg at 25°C
XLogP3:0
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:229.07389321
Heavy Atom Count:17
Complexity:324

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC2=C(C=CC3=C2C(C(C4C3O4)O)O)N=C1

Technology Process of anti-9,10-Dihydroxy-7,8-epoxy-7,8,9,10-tetrahydrobenzo(f)quinoline

There total 5 articles about anti-9,10-Dihydroxy-7,8-epoxy-7,8,9,10-tetrahydrobenzo(f)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 103620-39-9
9α,10β-diacetoxy-7α,8α-epoxy-7,8,9,10-tetrahydrobenzoquinoline

: 103620-40-2,119239-65-5,119478-48-7
(+/-)-9α,10β-dihydroxy-7α,8α-epoxy-7,8,9,10-tetrahydrobenzoquinoline

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 0 ℃; for 0.166667h;
DOI:10.1021/jo00368a001

Reference yield:

: 80028-83-7
7,8,9,10-tetrahydrobenzoquinoline

: 103620-40-2,119239-65-5,119478-48-7
(+/-)-9α,10β-dihydroxy-7α,8α-epoxy-7,8,9,10-tetrahydrobenzoquinoline

Guidance literature:: Multi-step reaction with 5 steps

2: 1.) N-bromosuccinimide(NBS), α,α'-azobis(isobutyronitrile)(AIBN), 2.) LiF, Li2CO3 / 1.) CCl4, 70-75 deg C, 30 min, 2.) HMPA, 80-85 deg C, 90 min

3: N-bromoacetanilide(NBS), concd. HCl / tetrahydrofuran / 3 h / 0 °C

4: n-Bu₄N+HSO₄-, Na₂CO₃ / CH₂Cl₂ / 1.25 h / 25 °C

5: 45 percent / 5percent NaOH / tetrahydrofuran; methanol / 0.17 h / 0 °C

With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); N-bromo-acetanilide; tetra(n-butyl)ammonium hydrogensulfate; lithium carbonate; sodium carbonate; lithium fluoride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo00368a001

Reference yield:

: 103620-33-3
trans-9,10-diacetoxy-9,10-dihydrobenzoquinoline

: 103620-40-2,119239-65-5,119478-48-7
(+/-)-9α,10β-dihydroxy-7α,8α-epoxy-7,8,9,10-tetrahydrobenzoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: N-bromoacetanilide(NBS), concd. HCl / tetrahydrofuran / 3 h / 0 °C

2: n-Bu₄N+HSO₄-, Na₂CO₃ / CH₂Cl₂ / 1.25 h / 25 °C

3: 45 percent / 5percent NaOH / tetrahydrofuran; methanol / 0.17 h / 0 °C

With hydrogenchloride; sodium hydroxide; N-bromo-acetanilide; tetra(n-butyl)ammonium hydrogensulfate; sodium carbonate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo00368a001