Technology Process of Copper, [4-(ethoxycarbonyl)phenyl]-
There total 3 articles about Copper, [4-(ethoxycarbonyl)phenyl]- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium naphthalide or lithium biphenylide;
In
tetrahydrofuran;
byproducts: CuBr; soln. of copper salt in THF quickly injected into stirring soln. of lithium salt (under Ar, via syringe, 5 min); addn. of alkyl halobenzoate to active Cu in THF (0°C, Cu/RX ratio = 3/1); stirring for 20 min;; not isolated; detn. by GC of secondary organic products;;
DOI:10.1021/om00040a028
- Guidance literature:
-
With
lithium naphthalide or lithium biphenylide;
In
1,2-dimethoxyethane;
byproducts: CuI; soln. of copper salt in DME quickly injected into stirring soln. of lithium salt (under Ar, via syringe, 5 min); addn. of alkyl halobenzoate to active Cu in DME (0°C, Cu/RX ratio = 3/1); stirring for 20 min;; not isolated; detn. by GC of secondary organic products;;
DOI:10.1021/om00040a028
- Guidance literature:
-
With
[Co(acac)2]; 4-fluorostyrene; Bu4NI;
In
tetrahydrofuran; further solvent(s);
byproducts: PhC6H4(CO2C2H5), CuOSO2(4-MeOC6H4), Ph2; react. of (C2H5O2C)C6H4(OSO2(C6H4NMe2)) (1 equiv.) with PhCu (3 equiv.) in presence of Co(acac)2 (20 mol%), 4-fluorostyrene (50 mol%) and Bu4NI (1 equiv.) in THF/(N,N'-dimethyl-N,N'-propylene urea (5:2) at 50°C for 5 h; Cu complex/PhC6H4(COOEt2) ratio up to 10:1;
DOI:10.1002/anie.200905379
