C₅₇H₆₁NO₁₆S

Base Information

• Chemical Name: C₅₇H₆₁NO₁₆S
• CAS No.: 160237-27-4
• Molecular Formula: C₅₇H₆₁NO₁₆S
• Molecular Weight: 1048.17
• Mol file: 160237-27-4.mol

Synonyms:

Chemical Property of C₅₇H₆₁NO₁₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₇H₆₁NO₁₆S

There total 13 articles about C₅₇H₆₁NO₁₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

dimethyl sulfoxide (67-68-5,8070-53-9) + 2’-carboxybenzoylpaclitaxel (148930-30-7) → C57H61NO16S (160237-27-4)

Guidance literature:

With acetic anhydride;

DOI:10.1016/0960-894X(96)00321-6

Reference yield:

7-O-(triethylsilyl)paclitaxel (148930-55-6) → C57H61NO16S (160237-27-4)

Guidance literature:

Multi-step reaction with 7 steps

1: benzoyl peroxide

2: HCl / acetonitrile

3: N-iodosuccinimide, 4 Angstroem sieves / CH₂Cl₂; tetrahydrofuran

4: H₂ / Pd-C / ethyl acetate / 2.5 h / 3102.9 Torr / Ambient temperature

5: bovine intestinal alkaline phosphatase

6: 93 percent / iPr₂EtN / CH₂Cl₂

7: 94 percent / Ac₂O

With hydrogenchloride; N-iodo-succinimide; 4 A molecular sieve; hydrogen; acetic anhydride; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile;

DOI:10.1016/0960-894X(96)00321-6

Reference yield:

taxol (33069-62-4) → C57H61NO16S (160237-27-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / iPr₂EtN / CH₂Cl₂

2: 94 percent / Ac₂O

With acetic anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/0960-894X(96)00321-6

upstream raw materials:

dimethyl sulfoxide

2’-carboxybenzoylpaclitaxel

taxol

benzyl chloroformate

Refernces