Technology Process of Acetic acid (2R,4aR,6R,7S,8S,8aR)-6-acetoxy-7-acetylamino-2-phenyl-hexahydro-benzo[1,3]dioxin-8-yl ester
There total 21 articles about Acetic acid (2R,4aR,6R,7S,8S,8aR)-6-acetoxy-7-acetylamino-2-phenyl-hexahydro-benzo[1,3]dioxin-8-yl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: toluene-p-sulfonic acid monohydrate / dimethylformamide / 1.5 h / 55 °C
2: sodium metaperiodate, sodium hydrogen carbonate / H2O / 5 h / 10 - 15 °C
3: sodium methoxide / methanol / 10 - 15 °C
4: 77 percent / H2 / Raney nickel T-4 / methanol / 40 h / 2585.7 Torr
5: pyridine / Ambient temperature
With
pyridine; sodium periodate; hydrogen; sodium methylate; sodium hydrogencarbonate; toluene-4-sulfonic acid;
Raney nickel T-4;
In
methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/0008-6215(88)85053-5
- Guidance literature:
-
Multi-step reaction with 8 steps
1: toluene-p-sulfonic acid monohydrate / dimethylformamide / 1.5 h / 55 °C
2: sodium metaperiodate, sodium hydrogen carbonate / H2O / 5 h / 10 - 15 °C
3: sodium methoxide / methanol / 10 - 15 °C
4: 77 percent / H2 / Raney nickel T-4 / methanol / 40 h / 2585.7 Torr
5: pyridine / Ambient temperature
6: 82 percent / pyridine / 6 h / Ambient temperature
7: anhydrous sodium acetate / 2-methoxy-ethanol; H2O / 30 h / 120 °C
8: pyridine / Ambient temperature
With
pyridine; sodium periodate; hydrogen; sodium methylate; sodium acetate; sodium hydrogencarbonate; toluene-4-sulfonic acid;
Raney nickel T-4;
In
methanol; 2-methoxy-ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/0008-6215(88)85053-5
- Guidance literature:
-
Multi-step reaction with 5 steps
1: toluene-p-sulfonic acid monohydrate / dimethylformamide / 1.5 h / 55 °C
2: sodium metaperiodate, sodium hydrogen carbonate / H2O / 5 h / 10 - 15 °C
3: sodium methoxide / methanol / 10 - 15 °C
4: 82 percent / H2 / Raney nickel T-4 / methanol / 40 h / 2585.7 Torr
5: pyridine / Ambient temperature
With
pyridine; sodium periodate; hydrogen; sodium methylate; sodium hydrogencarbonate; toluene-4-sulfonic acid;
Raney nickel T-4;
In
methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/0008-6215(88)85053-5
